摘要
目的:分析国家专利中药复方治疗慢性肾衰竭的用药规律。方法:以国家专利数据库中治疗慢性肾衰竭的中药复方为数据来源,筛选后运用Office Excel 2019建立数据库,再运用IBM SPSS Modeler 18.0、IBM SPSS Statistics 25.0、Cytoscape 3.7.1、中医传承辅助平台V2.5进行用药频数及性味归经统计、关联规则分析、因子分析、复杂网络图构建、熵层次聚类等。结果:纳入治疗慢性肾衰竭的中药复方专利共97首。高频药物有黄芪(48次,49.48%)、大黄(36次,37.11%)、茯苓(27次,27.84%)、白术(25次,25.77%)、丹参(25次,25.77%)等;功效以补虚类、利水渗湿药、清热药、活血化瘀药为主;药性以温、寒、平为主;药味多甘、苦、辛;归经以肝、脾、肺为主;关联分析共获得32组药对组合;因子分析共得到13个公因子;熵层次聚类算法发现候选处方4首。结论:专利中药复方治疗慢性肾衰竭重在补虚,以温阳利水、清热凉血、活血化瘀为主要治法,多选择利水渗湿、补气、清热、活血化瘀、补阳等药物治疗。
Objective:To analyze the medication rule of the national patented Chinese herbal compound prescriptions for the treatment of chronic renal failure.Methods:The Chinese medicine compound prescriptions for chronic renal failure in the national patent database were used as data source.After screening,a database was established using Office Excel 2019,and IBM SPSS Modeler 18.0,IBM SPSS Statistics 25.0,Cytoscape 3.7.1,Traditional Chinese Medicine Inheritance Support System V2.5 Medicine were employed for the analysis of frequency of usage,nature,flavor and meridian tropism of herbal medicines,association rule analysis,factor analysis,complex network construction,entropy hierarchical clustering,etc.Results:A total of 97 patented Chinese herbal compound prescriptions for the treatment of chronic renal failure were included,and high-frequency herbal medicines included Radix Astragali(48 times,49.48%),Radix et Rhizoma Rhei(36 times,37.11%),Poria(27 times,27.84%),Rhizoma Atractylodis Macrocephalae(25 times,25.77%),and Radix et Rhizoma Salviae Miltiorrhizae(25 times,25.77%).The medicines,mostly warm,cold and moderate,were mainly used for restoring qi,urine excretion to strain off dampness,clearing heat,activating blood and removing stasis and acted on the liver,spleen and lung.A total of 32 herbal combinations were obtained by association rule analysis,and 13 common factors were obtained by factor analysis.The entropy hierarchical clustering revealed four new prescriptions.Conclusion:The patented Chinese herbal compound prescriptions for chronic renal failure focuses on restoring qi,with the main treatment methods of warming yang,promoting urination,clearing heat,cooling blood,activating blood and removing stasis.The damp-draining diuretic and qi-tonifying,heat-clearing,blood-activating,stasis-removing and yang-tonifying medicines were mostly selected.
作者
王一帆
米娜
王希茜
申世雨
周晓洁
张琳琪
WANG Yifan;MI Na;WANG Xixi;SHEN Shiyu;ZHOU Xiaojie;ZHANG Linqi(Henan University of Chinese Medicine,Zhengzhou 450003,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450003,China)
出处
《世界中医药》
CAS
2023年第19期2825-2831,共7页
World Chinese Medicine
基金
第七批全国老中医药专家学术经验继承工作(国中医药人教函[2022]76号)
河南省中医药科学研究专项课题(2018ZDZX093)。
关键词
慢性肾衰竭
中药复方
国家专利数据库
关联规则
因子分析
中医传承辅助平台
数据挖掘
用药规律
Chronic renal failure
Chinese herbal compound prescription
National patent database
Association rules
Factor analysis
Traditional Chinese Medicine Inheritance Support System
Data mining
Medication rule
