摘要
帕金森病(PD)是最常见的神经系统退行性疾病,路易小体(LBs)是其最典型的病理改变。LBs的主要成分是α-突触核蛋白(α-syn),其被认为是PD的致病因子。传递假说认为,病理性α-syn可由受损神经元转运到正常神经元,导致受体神经元中α-syn也产生病理性错误折叠和聚集,导致级联式神经细胞受损。肠脑轴假说认为,病理性α-syn可由肠道产生,经由迷走神经上传至中枢神经系统。本文就α-syn在PD发病机制中的作用进行概述,以期为PD的干预靶点的研究提供参考。
Parkinson's disease(PD)is the most common neurodegenerative disease,and Lewy bodies(LBs)is the most typical pathological change.α-synuclein(α-syn),as the main component of LBs,is considered as the pathogenic factor of PD.According to the transmission hypothesis,pathologicalα-syn can be transported from damaged neurons to normal neurons,leading to pathological misfolding and aggregation ofα-syn in recipient neurons,resulting in cascading neuronal damage.According to the hypothesis of gut-brain axis,pathologicalα-syn can be produced in the intestine,and uploaded to the central nervous system via the vagus nerve.In this paper,the role ofα-syn in the pathogenesis of PD is summarized,in order to provide reference for the study of intervention targets of PD.
作者
刘柯婷
贺泽民
杨百元
钟成清
苟伟
肖莉
LIU Ke-ting;HE Ze-min;YANG Bai-yuan;ZHONG Cheng-qing;GOU Wei;XIAO Li(Department of Neurology,Chengdu Seventh People's Hospital,Chengdu Sichuan 610213,China;Department of Thoracic Surgery,West China(Airport)Hospital Sichuan University,Chengdu Sichuan 610200,China;Department of Human Anatomy and Histoembryology,Development and Regeneration Key Laboratory of Sichuan Province,Chengdu Medical College,Chengdu Sichuan 610500,China)
出处
《局解手术学杂志》
2023年第12期1091-1094,共4页
Journal of Regional Anatomy and Operative Surgery
基金
成都医学院院校联合基金(2021LHJYPJ-07)
成都市科研课题(2022103,2022307)
四川省教育厅项目(18ZB0179)。
