摘要
心境障碍是以显著而持久的心境或情感改变为主要特征的一组精神疾病,严重影响患者的社会生活。但目前心境障碍的发病机制尚不明确,缺乏特异性的生物学标记物辅助诊断,影响患者的诊断、治疗和预后。随着分子影像学的发展及应用增加,正电子发射断层扫描(positron emission tomography,PET)显示出其在心境障碍发病机制、鉴别诊断、疗效监测中的重要价值。本文旨在对心境障碍的PET显像原理以及发病和治疗相关机制的PET应用研究进展进行综述,并对PET在心境障碍中的应用前景进行总结展望。
Mood disorders are a group of mental conditions characterized by significant and lasting mood or emotional changes,which seriously affect patients′normal lives.However,the pathogenesis of mood disorders is still unclear,and the specific biological markers to assist the diagnosis are still not determined,and this affects the diagnosis,treatment and prognosis.With the development of molecular imaging,positron emission tomography(PET)has been widely used in clinical research on mood disorders,which is helpful for their clinical diagnosis and treatment.This paper aims to review the research progress on PET imaging principles,the pathogenesis and treatment mechanism of mood disorders,and to summarize the application prospect of PET in mood disorders.
作者
尹捷
何嘉丽
张剑昭
贾艳滨
Yin Jie;He Jiali;Zhang Jianzhao;Jia Yanbin(Department of Psychiatry,the First Affiliated Hospital of Jinan University,Guangzhou 510630,China)
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2023年第6期475-480,共6页
Chinese Journal of Psychiatry
基金
国家自然科学基金(82271564)
广州市科技计划项目(202201020047)。
