摘要
早期胚胎发育受到表观遗传的多重级联调控.组蛋白修饰是表观遗传调控的重要组成部分,组蛋白翻译后修饰通过影响组蛋白与DNA结合的紧密程度,调控染色质状态与基因表达,参与了胚胎发育及相关疾病发生的过程.在早期胚胎发育过程中,组蛋白甲基化修饰H3K4me3,H3K27me3与H3K9me3通过协调染色质的开放与关闭参与调控发育相关基因的表达,沉默逆转录转座子以及参与经典与非经典的印记调控.早期胚胎阶段作为表观遗传重编程的关键时间窗口,在此阶段组蛋白修饰酶的表达与组蛋白修饰容易受到不良环境的影响,导致胚胎期及子代多种疾病的发生.本文详细地对组蛋白H3K4me3,H3K27me3,H3K9me3修饰在早期胚胎发育与疾病发生中的作用与功能进行了综述,为今后表观遗传学在早期胚胎发育相关疾病的干预治疗提供理论基础.
Early embryonic development is regulated by multiple epigenetic cascades.Histone modification is an important part of epigenetic markers.Histone modification regulates chromatin state and gene expression by affecting the degree of histone binding to DNA that involves in the process of embryonic development and related diseases.Histone methylation H3K4me3,H3K27me3 and H3K9me3 modifications play important roles in early embryonic development via coordinating chromatin opening and closing to regulate the expression of development-related genes,silence retrotransposons,and participating in classical and non-classical imprinting regulation.Histone modification enzymes and histone modification are involved in the occurrence and progression of many diseases during embryonic period.In this review,we will summarize the roles and functions of H3K4me3,H3K27me3,and H3K9me3 modifications in regard to early embryonic development and disease occurrence,which will help to provide a theoretical basis for the epigenetic therapeutic interventions in early embryonic development related diseases in the future.
作者
柏丹丹
燕子回
刘善尧
刘文强
高绍荣
BAI DanDan;YAN ZiHui;LIU ShanYao;LIU WenQiang;GAO ShaoRong(School of Life Sciences and Technology,Tongji University,Shanghai 200092,China;Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital,Shanghai 201204,China;Jiaxing Maternity and Child Health Care Hospital,Jiaxing 314050,China)
出处
《中国科学：生命科学》
CSCD
北大核心
2023年第11期1564-1574,共11页
Scientia Sinica(Vitae)
基金
国家重点研发计划(批准号:2021YFA1102900)
国家自然科学基金创新研究群体项目(批准号:31721003)
中国博士后科学基金(批准号:2023M732660)资助。
关键词
组蛋白修饰
表观遗传
早期胚胎发育
胚胎发育异常
histone modification
epigenetic
early embryonic development
abnormal embryonic development
