摘要
目的探究经颅黑质超声在帕金森病(Parkinson’s disease,PD)中的诊断价值及不同黑质(substantia nigra,SN)回声患者的临床特征。方法选取2020年10月至2023年1月宜春市中医院收治的60例PD患者纳入研究组,另选取同期于本院接受健康检查的60名正常者纳入对照组,两组均予以经颅黑质超声检查。比较两组研究对象的SN高回声面积、双侧SN高回声总面积与中脑总面积的比值(ratio of total area of hyperechoic substantia nigra to total area of mesencephalon,S/M),统计经颅黑质超声诊断PD的阳性率。根据SN回声强度,将PD患者分成PD-SN-组、PD-SN+组,比较不同SN回声患者的临床特征。结果研究组患者的SN高回声面积、S/M均显著高于对照组(P<0.05);经颅黑质超声检查显示PD-SN-者10例,PD-SN+者50例,经颅黑质超声诊断PD的阳性率为83.33%(50/60)。PD-SN+组与PD-SN-组患者的性别、年龄、H-Y分期、发病年龄、简易精神状态检查量表评分及蒙特利尔认知评估量表评分比较,差异均有统计学意义(P<0.05)。结论经颅黑质超声能更好地帮助临床筛查和发现PD,提高PD阳性检出率。
Objective To explore the diagnostic value of transcranial substantia nigra ultrasound in Parkinson’s disease(PD)and the clinical characteristics of patients with different substantia nigra(SN)echoes.Methods Sixty patients with PD admitted to Yichun Hospital of Traditional Chinese Medicine from October 2020 to January 2023 were included in study group,and another 60 normal persons who received health examination in our hospital during the same period were included in control group.Both groups were examined by transcranial substantia nigra ultrasound.The SN high-echo area and ratio of total area of hyperechoic substantia nigra to total area of mesencephalon(S/M)of two groups were compared,and the positive rate of PD diagnosed by transcranial substantia nigra ultrasound was calculated.According to the intensity of SN echo,PD patients were divided into PD-SN-group and PD-SN+group,and the clinical characteristics of patients with different SN echo were compared.Results The SN high-echo area and S/M of study group were significantly higher than those of control group(P<0.05).Transcranial substantia nigra ultrasound showed PD-SN-in 10 cases and PD-SN+in 50 cases.The positive rate of PD diagnosed by transcranial substantia nigra ultrasound was 83.33%(50/60).There were statistically significant differences between PD-SN+group and PD-SN-group in gender,age,H-Y stage,age of onset,score of mini mental status examination and score of Montreal cognitive assessment(P<0.05).Conclusion Transcranial substantia nigra ultrasound can better help clinical screening and detection of PD,and improve the positive detection rate of PD.
作者
张美霞
乔璐
胡淑云
ZHANG Meixia;QIAO Lu;HU Shuyun(Department of Ultrasound Medicine,Yichun Hospital of Traditional Chinese Medicine,Yichun 336000,Jiangxi,China;Department of Internal Medicine,Yichun Hospital of Traditional Chinese Medicine,Yichun 336000,Jiangxi,China)
出处
《中国现代医生》
2023年第34期60-62,99,共4页
China Modern Doctor
关键词
帕金森病
经颅黑质超声
诊断价值
黑质回声
临床特征
Parkinson’s disease
Transcranial substantia nigra ultrasound
Diagnostic value
Substantia nigra echo
Clinical characteristics
