摘要
目的:探讨2型糖尿病(T2DM)采取早期胰岛素强化治疗对改善疗效及胰岛功能的影响。方法:选择2021年1月—2022年12月我院收治的T2DM患者150例研究,双色球法分为两组,对照组采用口服降糖药物治疗,观察组采用早期胰岛素强化治疗,对比效果。结果:观察组总有效率高于对照组(P<0.05);治疗前两组血糖、血脂、胰岛功能指标无明显差异(P>0.05),治疗后观察组空腹血糖、餐后2h血糖、糖化血红蛋白、甘油三酯、总胆固醇、HOMA-IR低于对照组,而HOMA-β高于对照组,差异显著(P<0.05);两组用药期间低血糖发生率无明显差异(P>0.05)。结论:T2DM患者采取早期胰岛素强化治疗,与口服降糖药物比较,可提高疗效,而且更好地改善患者的血糖与血脂指标,且能促进胰岛功能改善,而低血糖发生率低,值得应用。
Objective:To investigate the effect of early intensive insulin therapy on the curative effect and islet function of type 2 diabetes mellitus(T2DM).Methods:150 T2DM patients admitted to our hospital from January 2021 to December 2022 were divided into two groups by bicolor sphere method.The control group was treated with oral hypoglycemic drugs,and the observation group was treated with early insulin intensive therapy to compare the effect.Results:The total effective rate of observation group was higher than that of control group(P<0.05).There were no significant differences in blood glucose,blood lipid and islet function indexes between the two groups before treatment(P>0.05).After treatment,fasting blood glucose,2h postprandial blood glucose,glycated hemoglobin,triglyceride,total cholesterol and HOMA-IR in the observation group were lower than those in the control group,while HOMA-βwas higher than those in the control group,with significant differences(P<0.05).There was no significant difference in the incidence of hypoglycemia between the two groups(P>0.05).Conclusion:Compared with oral hypoglycemic drugs,early intensive insulin therapy in T2DM patients can improve the curative effect,better improve the blood glucose and lipid indexes of patients,and promote the improvement of islet function,and the incidence of hypoglycemia is low,which is worthy of application.
作者
宋志军
谷娟
Song Zhijun(Xingang Community Health Service Center,Tanggu Street,Binhai New Area,Tianjin 300456)
出处
《黑龙江医药》
CAS
2023年第6期1364-1366,共3页
Heilongjiang Medicine journal
关键词
2型糖尿病
早期胰岛素强化治疗
口服降糖药物
疗效
胰岛功能
Type 2 diabetes mellitus
Early intensive insulin therapy
Oral hypoglycemic drugs
Curative effect
Islet function
