摘要
目的:构建个体化预测前列腺增生患者经尿道电切术后发生尿道狭窄的风险列线图模型。方法:收集2019年1月~2022年12月德驭医疗马鞍山总医院行经尿道电切术的前列腺增生患者的临床资料,使用单因素和多因素Logistic回归分析术后发生尿道狭窄的独立危险因素,同时建立相关列线图模型,并采用Bootstrap法对模型进行验证。结果:尿道感染、术前前列腺体积较大、TURP手术类型、手术时间较长、持续牵引时间较长和尿管留置时间≥7d是前列腺增生患者经尿道电切术后发生尿道狭窄的独立危险因素(P<0.05)。模型验证结果显示,C-index指数为0.889(95%CI:0.855~0.923),模型的校准曲线和理想曲线拟合较好,ROC曲线的AUC为0.881(95%CI:0.843~0.911),在5%~98%范围内,模型净获益。结论:基于前列腺增生患者经尿道电切术后发生尿道狭窄的独立危险因素建立的列线图模型具有良好的预测效能。
Objective:To establish a nomogram model to predict the risk of urethral stricture in patients with benign prostatic hyperplasia after transurethral resection.Methods:The clinical data were included in patients with benign prostatic hyperplasia undergone transurethral resection in our hospital between January 2019 and December 2022.The independent risk factors of postoperative urethral stricture were analyzed using single factor and multivariate logistic regression models,and the relevant nomograph was established and verified by Bootstrap method.Results:Urethral infection,large preoperative prostate volume,TURP,long operative time,long continuous traction time and indwelling time of urinary catheter≥7 days were independent risk factors for urethral stricture in patients with benign prostatic hyperplasia after transurethral resection(P<0.05).The model validation results showed that the C-index was 0.889(95%CI:0.855-0.923),the calibration curve was well fitted with ideal curve of the model,and the AUC of the ROC curve was 0.881(95%CI:0.843-0.911).The model had a net benefit in the range of 5%-98%.Conclusion:The nomogram established based on the independent risk factors can be better predictive for urethral stricture in patients with prostate hyperplasia after transurethral resection.
作者
王虓
张征宇
何海兵
吴华晨
唐国庆
WANG Xiao;ZHANG Zhengyu;HE Haibing;WU Huachen;TANG Guoqing(Department of Urology,Ma′anshan General Hospital of Ranger-Duree Healthcare,Ma′anshan 243000,China)
出处
《皖南医学院学报》
CAS
2023年第6期540-544,共5页
Journal of Wannan Medical College
基金
安徽高校自然科学研究项目(KJ2021A1186)。
关键词
前列腺增生
经尿道电切术
尿道狭窄
危险因素
列线图
prostatic hyperplasia
transurethral resection
urethral stricture
risk factors
nomogram
