摘要
目的观察消风散结汤加减辅助治疗小儿腺体样肥大肺脾气虚型的临床疗效。方法选取2019年6月至2022年7月在兰溪市人民医院中医儿科就诊的腺样体肥大肺脾气虚型患儿60例,采用随机数字表法分为对照组和治疗组,各30例。对照组给予布地奈德吸入气雾剂喷鼻,治疗组在对照组治疗方法的基础上给予消风散结汤加减治疗。2组均1个月为1个疗程,连续治疗2个月后统计临床疗效。结果对照组总有效率为73.33%(22/30),治疗组为93.33%(28/30),2组比较,差异有统计学意义(P<0.05)。治疗前,2组鼻塞打鼾、张口呼吸、胸闷憋气、呼吸反复暂停、嗜睡中医证候积分比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组上述中医证候积分均显著下降,与同组治疗前比较,差异有统计学意义(P>0.05),且治疗组下降更显著(P<0.05)。治疗前,2组血清特异性IgE(sIgE)、可溶性白介素-2受体(sIL-2R)、肿瘤坏死因子-α(TNF-α)、白细胞介素-4(IL-4)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组血清sIgE、sIL-2R、TNF-α、IL-4水平均显著降低,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组降低更显著(P<0.05)。治疗前,2组疾病特异性生活质量调查(OSA-18)量表评分比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组OSA-18量表评分均显著下降,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。结论消风散结汤加减辅助治疗小儿腺体样肥大肺脾气虚型,能明显改善患儿的临床症状、体征,减轻机体炎症损伤程度,提高生活质量,疗效显著,值得临床推广应用。
Objective To observe the clinical efficacy of modified Xiaofeng Sanjie Tang(消风散结汤)in ad⁃juvant treatment of pediatric adenoid hypertrophy of lung,spleen and qi deficiency type.Methods Sixty children with adenoid hypertrophy of lung,spleen and qi deficiency type who were treated in the traditional Chinese medicine(TCM)Pediatrics Department of Lanxi People’s Hospital from June 2019 to July 2022,were divided into a control group and a treatment group using a random number table,with 30 cases in each group.The control group was trea⁃ted with budesonide inhalation aerosol nasal spray,while the treatment group was treated with modified Xiaofeng Sanjie Tang on the basis of the control group’s treatment method.Both groups were treated for one month as a course of treatment,and the clinical efficacy was calculated after two consecutive months of treatment.Results The total effective rate of the control group was 73.33%(22/30),while that of the treatment group was 93.33%(28/30).The difference between the two groups was statistically significant(P<0.05).Before treatment,there was no statisti⁃cally significant difference(P>0.05)in the TCM syndrome scores of nasal congestion,snoring,open mouth breath⁃ing,chest tightness,suffocation,repeated respiratory pauses,and drowsiness between the two groups,indicating com⁃parability.After treatment,the TCM syndrome scores mentioned above in both groups significantly decreased,with a statistically significant difference compared to the same group before treatment(P<0.05),and the decrease in the treatment group was more significant(P<0.05).Before treatment,the comparison between two groups of serum spe⁃cific IgE(sIgE),soluble interleukin⁃2 receptor(sIL⁃2R),tumor necrosis factor⁃α(TNF⁃α),and interleukin⁃4(IL⁃4)levels showed no statistically significant difference(P>0.05),indicating comparability.After treatment,the levels of serum sIgE,sIL⁃2R,TNF⁃αand IL⁃4 in both groups were significantly reduced compared to the same group before treatment,with a statistically significant difference(P<0.05),and the treatment group showed a more signifi⁃cant decrease(P<0.05).Before treatment,there was no statistically significant difference(P>0.05)in the scores of the two disease specific quality of life surveys(OSA⁃18),indicating comparability.After treatment,the OSA⁃18 scale scores of both groups significantly decreased,with a statistically significant difference compared to the same group before treatment(P<0.05),and the treatment group showed a more significant decrease(P<0.05).Conclu⁃sion The modified Xiaofeng Sanjie Tang can significantly improve clinical symptoms and signs of children with ad⁃enoid hypertrophy of lung,spleen and qi deficiency type,reduce the degree of inflammation and damage to the body,improve the quality of life,and have a significant therapeutic effect.It is worth popularizing in clinical practice.
作者
方翔
FANG Xiang(Department of TCM Pediatrics,Lanxi People’s Hospital,Lanxi,Zhejiang,321100,China)
出处
《中医儿科杂志》
2023年第6期59-63,共5页
Journal of Pediatrics of Traditional Chinese Medicine
关键词
小儿
腺样体肥大
肺脾气虚型
消风散结汤
炎症因子
临床观察
children
adenoid hypertrophy
spleen and qi deficiency type
Xiaofeng Sanjie Tang(消风散结汤)
inflammatory factors
clinical observation
