摘要
目的分析探讨阿司匹林联合免疫球蛋白(IVIG)对川崎病患儿临床表现消退时间、白细胞计数(WBC)、C反应蛋白(CRP)、血小板计数(PLT)和红细胞沉降素(ESR)的影响。方法选取汝南县人民医院于2017年2月-2022年2月收治的50例川崎病患儿,按照随机数字表法将患者分为对照组和试验组,两组均给予静脉注射IVIG治疗,试验组在此基础上联合使用阿司匹林口服治疗,观察两组颈淋巴结肿大消退时间和黏膜充血消退时间、退热时间以及手足肿胀消退时间等,比较两组WBC和CRP水平以及PLT和血沉指标等。结果治疗后试验组手足肿胀消退时间和颈淋巴结肿大消退时间、黏膜充血消退时间以及退热时间等均显著低于对照组(P<0.05)。治疗后的WBC、CRP、PLT和ESR等水平显著低于治疗前(P<0.05),试验组WBC、CRP、PLT和ESR等水平显著低于对照组(P均<0.05)。结论对川崎病患儿联合采用阿司匹林和IVIG进行治疗能够有效缩短患儿临床表现的消退时间,大大改善患儿WBC、CRP、PLT、以及ESR等水平,疗效确切,值得在临床上加以推广运用。
Objective To analyze and explore the effects of aspirin combined with immunoglobulin(IVIG)on the clinical manifestation regression time,white blood cell count(WBC),C-reactive protein(CRP),platelet count(PLT),and erythrocyte sedimentation factor(ESR)levels in children with Kawasaki disease.Methods 50 children with Kawasaki disease admitted to the hospital from February 2017 to February 2022 were selected and divided into the control group and the experimental group according to the method of random number table.Both groups were treated with intravenous IVIG,and the experimental group was treated with oral aspirin on this basis.The time for cervical lymph node swelling to subside and mucosal congestion to subside,the time for fever to subside and the time for swelling of hands and feet to subside in the two groups were observed,and the WBC,CRP,PLT and blood sedimentation indexes in the two groups were compared.Results After treatment,the time for cervical lymph node swelling to subside and mucosal congestion to subside,the time for fever to subside and the time for swelling of hands and feet to subside in the experimental group were significantly lower than those in the control group(P<0.05).The levels of WBC,CRP,PLT and ESR after treatment were significantly lower than those before treatment(P<0.05),and the levels of WBC,CRP,PLT and ESR in the experimental group were significantly lower than those in the control group(all P<0.05).Conclusion The combined use of aspirin and gammaglobulin in the treatment of children with Kawasaki disease can effectively shorten the time for the children’s clinical manifestations to subside.It greatly improved the levels of WBC,CRP,PLT,and ESR,and the therapeutic effect is accurate,and it is worth to promote the use in the clinic.
作者
张贺霞
蓝世群
徐文娟
ZHANG Hexia;LAN Shiqun;XU Wenjuan(Department of Pediatrics,Runan People’s Hospital,Runan 463300,China)
出处
《湖北民族大学学报（医学版）》
2023年第4期51-54,共4页
Journal of Hubei Minzu University(Medical Edition)
