摘要
目的分析影响益气活血法治疗冠心病心力衰竭(气虚血瘀证)临床疗效的相关因素。方法收集整理80例接受益气活血法治疗的冠心病心力衰竭(气虚血瘀证)患者治疗前及治疗3个月时的一般资料、心功能指标、能量代谢指标、凝血功能指标、炎性因子指标、合并疾病、合并用药。80例接受益气活血法治疗的受试者,以治疗3个月时N末端B型利钠肽原(NT-proBNP)较基线降幅≥30%为有效,分为有效组和无效组。采用组间比较、Spearman相关分析及二元Logistic回归等方法进行单因素和多因素分析,筛选出影响益气活血法治疗冠心病心力衰竭(气虚血瘀证)临床疗效的相关因素,三种方法同时被两种方法筛选出的视为最终影响因素。结果秩和检验或卡方检验筛选出的影响因素有血清葡萄糖转运蛋白-1(GLUT-1)、血清葡萄糖转运蛋白-4(GLUT-4)、白细胞介素-1β(IL-1β)、β受体阻滞剂(P<0.05)等;Spearman相关分析筛选出的影响因素有GLUT-1(r=-0.266)、GLUT-4(r=-0.285)、IL-1β(r=-0.252)、β受体阻滞剂(r=0.274)等;二元Logistic回归多因素分析筛选出的影响因素有GLUT-4(P=0.028)、β受体阻滞剂(P=0.042)。结论影响益气活血法治疗冠心病心力衰竭(气虚血瘀证)临床疗效的相关因素包括GLUT-1、GLUT-4、IL-1β、β受体阻滞剂。
Objective To analyze the related factors affecting the clinical efficacy of invigorating Qi and activating blood circula-tion in the treatment of coronary heart failure(Qi deficiency and blood stasis syndrome).Methods The general data,cardiac function indexes,energy metabolism indexes,coagulation function indexes,inflammatory factor indexes,combined diseases and combined medication of 80 patients with coronary heart disease and heart failure(Qi deficiency and blood stasis syndrome)trea-ted and after treatment for 3 months were collected and analyzed.80 subjects were treated with the benefit of Qi and blood circula-tion method.The reduction of N-terminal B-type natriuretic peptide(NT-proBNP)from baseline at 3 months was effective,and they were divided into effective group and invalid group.Univariate and multivariate analyses were conducted by inter-group comparison,Spearman correlation analysis,binary Logistic regression and other methods to identify the relevant factors influencing the clinical efficacy of the method of invigorating qi and promoting blood circulation in the treatment of CHD heart failure(Qi defi-ciency and blood stasis syndrome).The three methods were simultaneously screened by the two methods as the final influencing factors.Results The rank sum test or Chi-sguare test screened serum glucose transporter-1(GLUT-1),serum glucose trans-porter-4(GLUT-4),interleukin-1β(IL-1β)andβ-blocker(P<0.05).Spearman correlation analysis showed that GLUT-1(r=-0.266),GLUT-4(r=-0.285),IL-1β(r=-0.252)andβ-blocker(r=-0.274)were the most significant factors.GLUT-4(P=0.028)andβ-blocker(P=0.042)was screened by multivariate Logistic regression analysis.Conclusion The clinical effect of invigorating Qi and promoting blood circulation in the treatment of CHD heart failure(Qi-deficiency and blood stasis syndrome)is affected by GLUT-1,GLUT-4,IL-1βandβ-blocker.
作者
孙恒
邢作英
徐晓燕
李彬
王新陆
王永霞
SUN Heng;XING Zuo-ying;Xu Xiao-yan;LI Bin;WANG Xin-lu;WANG Yong-xia(Henan University of Chinese Medicine,Zhengzhou 450000,China;First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《时珍国医国药》
CAS
CSCD
北大核心
2023年第9期2160-2164,共5页
Lishizhen Medicine and Materia Medica Research
基金
国家重点基础研究发展计划(“973”计划)(2015CB554401)。
关键词
冠心病
心力衰竭
气虚血瘀证
益气活血法
临床疗效
影响因素
Coronary heart disease
Heart failure
Qi deficiency and blood stasis syndrome
Invigorating Qi and activa-ting blood circulation
Clinical efficacy
Influencing factors
