摘要
目的探讨新型细胞因子白细胞介素-38(IL-38)在强直性脊柱炎(AS)患者中的表达变化及临床意义。方法选取2023年1月至5月九江市第一人民医院收治的80例AS患者设为观察组,80例健康体检者作为对照组,检测调节性T细胞(Treg)细胞和辅助性T细胞17(Th17)细胞比率、IL-38、白细胞介素-17(IL-17)、白细胞介素-10(IL-10)、C反应蛋白(CRP)、红细胞沉降率(ESR),比较两组IL-38、IL-17、IL-10、CRP、ESR水平和Th17、Treg细胞比率,分析IL-38水平与Th17、Treg细胞比率和IL-17、IL-10、CRP、ESR之间的相关性,并记录AS患者巴氏Bath强直性脊柱炎病情活动指数(BASDAI)、强直性脊柱炎病情活动度(ASDAS)评分,分析其与IL-38之间的相关性。结果观察组IL-17、CRP、ESR、Th17细胞比率高于对照组,IL-38、Treg细胞比率、IL-10低于对照组,差异有统计学意义(P<0.05);IL-38水平与AS患者IL-17、CRP、ESR、Th17细胞比率呈负相关,与Treg细胞比率、IL-10呈正相关(P<0.05);AS患者BASDAI评分为(3.50±1.11)分,ASDAS评分为(2.96±0.67)分。IL-38与AS患者BASDAI、ASDAS评分均呈负相关(P<0.05)。结论AS患者中IL-38水平降低,其与患者病情活动、炎症活动指标密切相关,可能参与疾病发生与进展。
Objective To investigate the expression and clinical significance of novel cytokine interleukin-38(IL-38)in patients with ankylosing spondylitis(AS).Methods A total of 80 patients with AS treated in Jiujiang NO.1 People's Hospital from January to May 2023 were selected as the observation group,and 80 healthy subjects were selected as the control group.The ratio of regulatory T cells(Treg)to T helper cell 17(Th17),IL-38,interleukin-17(IL-17),interleukin-10(IL-10),C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)were detected.The levels of IL-38,IL-17,IL-10,CRP,ESR and the ratio of Th17,Treg cells were compared between the two groups,and the correlation between the levels of IL-38,the ratio of Th17,Treg cells and IL-17,IL-10,CRP and ESR were analyzed.The bath ankylosing spondylitis activity index(BASDAI)and ankylosing spondylitis disease activity score(ASDAS)of AS patients were recorded,and the correlation between these indexes and IL-38 were analyzed.Results IL-17,CRP,ESR and the ratios of Th17 cells in observation group were higher than those in control group,while IL-38,the ratios of Treg cells and IL-10 were lower than those in control group,with statistical significances(P<0.05).IL-38 level was negatively correlated with IL-17,CRP,ESR and the ratio of Th17 cells,and positively correlated with the ratio of Treg cells and IL-10 in AS patients(P<0.05).The BASDAI score and ASDAS score of AS patients were(3.50±1.11)and(2.96±0.67)point.IL-38 was negatively correlated with BASDAI and ASDAS scores in AS patients(P<0.05).Conclusion The decrease of IL-38 level in AS patients is closely related to the disease activity and inflammatory activity indicators of patients,and may be involved in the occurrence and progression of the disease.
作者
董亮
刘炬
李学勇
DONG Liang;LIU Ju;LI Xueyong(Department of Rheumatology and Immunology,Jiujiang NO.1 People's Hospital,Jiangxi Province,Jiujiang332000,China)
出处
《中国当代医药》
CAS
2023年第35期45-48,共4页
China Modern Medicine
基金
江西省卫生健康委科技计划项目(202140324)。
