摘要
目的:探究分析肺癌患者化疗后肺部感染发生情况及影响因素。方法:选取2020年1月—2022年9月福建医科大学附属泉州第一医院收治的230例肺癌患者为研究对象,对其化疗后肺部感染发生率进行统计,比较不同性别、年龄、白蛋白水平、血红蛋白水平、中性粒细胞情况、合并基础疾病情况、肺不张情况、卡氏功能状态评分(KPS评分)、分化程度、TNM分期、化疗药物种类、化疗时间、放疗情况及侵入性操作情况患者的肺部感染发生率,采用多因素logistic分析肺癌患者化疗后肺部感染发生的影响因素。结果:230例肺癌患者化疗后29例发生肺部感染,发生率为12.61%。不同性别及分化程度患者的肺部感染发生率比较,差异均无统计学意义(P>0.05);年龄≥65岁、白蛋白<35 g/L、血红蛋白<110 g/L、中性粒细胞减少、合并基础疾病、肺不张、KPS评分<80分、TNMⅢ~Ⅳ期、化疗药物两种及以上、化疗>2个周期、进行放疗及侵入性操作患者的肺部感染发生率均显著高于年龄<65岁、白蛋白≥35 g/L、血红蛋白≥110 g/L、中性粒细胞正常、无基础疾病、无肺不张、KPS评分≥80分、TNMⅠ~Ⅱ期、化疗药物种类一种、化疗2个周期、无放疗及无侵入性操作患者,差异均有统计学意义(P<0.05)。多因素logistic分析显示,年龄、白蛋白水平、血红蛋白水平、中性粒细胞情况、合并基础疾病情况、肺不张情况、KPS评分、TNM分期、化疗药物种类、化疗时间、放疗情况及侵入性操作情况是肺癌患者化疗后肺部感染发生的影响因素(P<0.05)。结论:肺癌患者化疗后肺部感染发生率较高,且影响肺部感染发生的因素涉及面较广。
Objective:To investigate and analyze the incidence and influencing factors of pulmonary infection in patients with lung cancer after chemotherapy.Method:A total of 230 patients with lung cancer admitted to Quanzhou First Hospital Affiliated to Fujian Medical University from January 2020 to September 2022 were selected as the study objects,and the incidence of pulmonary infection after chemotherapy was statistically analyzed.The incidence of pulmonary infection in patients with different gender,age,albumin level,hemoglobin level,neutrophil status,combined underlying medical conditions status,pulmonary atelectasis status,Karnofsky functional status score(KPS score),differentiation degree,TNM stage,type of chemotherapeutic drug,duration of chemotherapy,radiotherapy status and intrusive operating status were compared.The influencing factors of pulmonary infection in patients with lung cancer after chemotherapy was analyzed by multivariate logistic.Result:Among 230 patients with lung cancer,29 cases developed pulmonary infection after chemotherapy,with an incidence of 12.61%.There were no significant difference in the incidence of pulmonary infection in patients with different gender and differentiation degree(P>0.05).The incidence of pulmonary infection in patients with age≥65 years old,albumin<35 g/L,hemoglobin<110 g/L,neutropenia,combined underlying medical conditions,pulmonary atelectasis,KPS score<80 scores,TNMⅢ-Ⅳstage,two or more type of chemotherapeutic drug,chemotherapy>2 cycles,with radiotherapy and with intrusive operating were significantly higher than those of patients with age<65 years old,albumin≥35 g/L and hemoglobin≥110 g/L,normal neutrophil,no underlying medical conditions,no pulmonary atelectasis,KPS score≥80 scores,TNMⅠ-Ⅱstage,one type of chemotherapeutic drug,2 cycles of chemotherapy,no radiotherapy and intrusive operating(P<0.05).Multivariate logistic analysis showed that age,albumin level,hemoglobin level,neutrophil status,combined underlying medical conditions status,pulmonary atelectasis status,KPS score,differentiation degree,Medical Innovation of China Vol.20,No.34 December,2023 TNM stage,type of chemotherapeutic drug,duration of chemotherapy,radiotherapy status and intrusive operating status were the influencing factors for pulmonary infection in patients with lung cancer after chemotherapy(P<0.05).Conclusion:The incidence of pulmonary infection in patients with lung cancer after chemotherapy is higher,and the factors affecting the occurrence of pulmonary infection involve a wide range.
作者
陈力津
CHEN Lijin(Quanzhou First Hospital Affiliated to Fujian Medical University,Quanzhou 362000,China)
出处
《中国医学创新》
CAS
2023年第34期157-161,共5页
Medical Innovation of China
关键词
肺癌
化疗
肺部感染
影响因素
Lung cancer
Chemotherapy
Pulmonary infection
Influencing factors
