摘要
外固定器作为最常见的固定装置在开放性骨折手术中被大量应用,但其配合使用的螺钉存在易感染的问题。采用射频磁控溅射技术制备Ag-ZnO/Ti纳米复合涂层附着于Ti6Al4V螺钉表面,能够有效减少细菌的粘附。通过调整靶材拼接的比例,探究了不同Ag含量的复合涂层微观形貌对Ti6Al4V螺钉抗菌性能的影响。结果表明,当Ag、ZnO、Ti靶材的拼接体积比为2∶2∶96时,Ag-ZnO/Ti纳米复合涂层中Ag质量分数达到1.85%,其表面粗糙度为4.24 nm,涂层表面平整光滑且具有疏水性,有利于减少细菌的粘附。涂层细胞毒性符合生物安全标准,且抗菌率高达99.62%。
External fixators,as the most common fixation devices,are widely used in open bone fracture surgeries.However,screws used in conjunction with external fixators are susceptible to infection.Utilizing radio frequency magnetron sputtering technology to prepare Ag-ZnO/Ti nano-composite coatings adhered to the surface of Ti6Al4V screws,it is possible to effectively reduce bacterial adhesion.By adjusting the ratio of target material bonding,the effect of the microstructure of different Ag content in composite coatings on the antibacterial performance of Ti6Al4V screws were investigated.The results indicate that when the volume ratio of Ag,ZnO,Ti target materials are 2:2:96,the mass fraction of Ag in the Ag-ZnO/Ti nanocomposite coating reaches 1.85%,with a roughness of 4.24 nm.The coating surface is smooth and hydrophobic,which is conducive to reducing bacterial adhesion.The cytotoxicity of the coating meets the biosafety standard,with the antibacterial rate as high as 99.62%.
作者
李伟
张卓
张镨丹
章浩
马迅
LI Wei;ZHANG Zhuo;ZHANG Pudan;ZHANG Hao;MA Xun(School of Materials and Chemistry,University of Shanghai for Science and Technology,Shanghai 200093,China;Orthopedic trauma,Changhai Hospital of Shanghai,Shanghai 200433,China)
出处
《有色金属材料与工程》
CAS
2023年第6期1-9,共9页
Nonferrous Metal Materials and Engineering
基金
国家自然科学基金资助项目(51971148)。
关键词
复合涂层
银
微观形貌
细胞毒性
抗菌性能
composite coating
silver
microstructure
cytotoxicity
antibacterial property
