摘要
背景:《景岳全书》为明代医家张介宾(号景岳)集历代医家之思想精粹,总结自身临床经验所撰,全书系统地论述了各科疾病的病因病机与理法方药,多为后世医家所推崇。在《景岳全书·妇人规》中,对“产后”这一妇女特殊的生理状态进行了详细的生理及病理论述,并记载了产后病相关的治疗方剂。目的:文章通过数据挖掘,拟探究《景岳全书·妇人规》产后疾病的用药规律。方法:收集《景岳全书·妇人规》产后类方剂,通过中医传承计算平台V3.0(TCMICS V3.0)对药物的使用频次进行分析,同时使用关联规则分析,k均值聚类算法与回归模型进行聚类分析,使用Excel 16.65对药物四气、五味、归经及功效进行分析。结果:共筛选出方剂63首,涉及中药92味。药物出现频次前五分别是当归、炙甘草、熟地黄、白芍、人参。药性以温药占比最高,之后为平性。药味以甘药为主,苦味次之。药物归经归脾经最多,其次为肝经、心经。功效占比最高为补虚类,其后为理气类、活血化瘀类。使用关联规则分析得到常用配伍组合11组,药物关联规则7组。使用聚类分析得到4类核心药物组合。结论:妇人在产后这一特殊时间,气血随胎而去,张介宾作为温补学派的代表人物,治疗产后类病常常以调补气血为原则,遣方用药多以甘温补脾为主,常配伍理气类、活血化瘀类、清热类药。注重全身脏腑气血之间的关联,强调“因证用治,随证治之”。
Background:Jingyue Quanshu(《景岳全书》)was written by ZHANG Jiebin,a Ming dynasty medicine practitioner,who gathered the essence of ideas of successive generations of doctors and summarized his clinical experience.The book systematically discusses the etiology and pathogenesis of various diseases,as well as the theory,method and prescriptions,which were mostly respected by later generations of doctors.In Jingyue Quanshu·Furen Gui(《景岳全书·妇人规》),the special physiological state of women after childbirth is discussed in detail in terms of physiology and pathology,and the treatment prescriptions related to postpartum diseases are also recorded.Objective:Through data mining,this paper intends to investigate medication rules for postpartum diseases in Jingyue Quanshu·Furen Gui.Methods:By collecting postpartum class prescriptions from Jingyue Quanshu·Furen Gui,the frequency of drug use was analyzed by TCMICS V3.0,as well as cluster analysis by using association rule analysis,k-means clustering algorithm and regression model,and analysis of the four Qi(气),five tastes,attribution and efficacy of drugs by using Excel 16.65.Results:A total of 63 prescriptions were screened,involving a total of 92 herbal medicines.The top five drug occurrences were Danggui(Radix Angelicae Sinensis),Zhigancao(Radix Glycyrrhizae),Shudihuang(Radix Rehmanniae Preparata),Baishao(Radix Paeoniae Alba),Renshen(Radix Ginseng).The highest proportion of medicinal properties were warm medicines,followed by flat ones.The taste of medicine is mainly sweet medicine,followed by bitter taste.Drug meridian belongs to the spleen meridian the most,followed by liver meridian and heart meridian.The highest proportion of efficacy was in the category of tonifying deficiency,followed by the category of regulating Qi and activating blood circulation to remove blood stasis.Using association rule analysis,eleven groups of commonly used combinations and 7 groups of drug association rules were obtained.Using cluster analysis,four groups of core drug combinations were obtained.Conclusion:As a representative of the school of warming and tonicity,ZHANG Jiebin,in the treatment of postpartum diseases,often takes the principle of tonifying Qi and blood,and uses prescriptions that are mainly sweet and warm to nourish the spleen,often combined with drugs that regulate Qi,invigorate blood and remove stasis,and clear heat.He emphasizes the connection between Qi and blood in the internal organs of the body,and stresses treating according to the TCM syndrome and following the TCM syndrome.
出处
《中医临床研究》
2023年第31期77-81,共5页
Clinical Journal Of Chinese Medicine
关键词
数据挖掘
《景岳全书》
产后病
Data mining
Jingyue Quanshu
Postnatal illness
