摘要
目的分析乌拉地尔联合硫酸镁、阿司匹林治疗妊娠期高血压疾病的效果及对微环境炎症的影响。方法选择2021年1月至2022年3月我院收治的80例妊娠期高血压疾病患者作为研究对象,以随机数字表法将其分为对照组和观察组,每组40例。对照组给予硫酸镁、阿司匹林治疗,观察组在对照组治疗基础上加施乌拉地尔治疗。比较两组的治疗效果。结果治疗后,观察组的收缩压、舒张压、尿蛋白含量低于对照组(P<0.05)。治疗后,观察组的可溶性白细胞介素-2受体(sIL-2R)、核因子-κB(NF-κB)、高迁移率族蛋白B1(HMGB1)水平低于对照组(P<0.05)。治疗后,观察组的内皮素-1(ET-1)水平低于对照组,血管内皮生长因子(VEGF)、血小板内皮细胞黏附分子-1(PECAM-1)水平高于对照组(P<0.05)。观察组的不良妊娠总发生率显著低于对照组(P<0.05)。结论乌拉地尔联合硫酸镁、阿司匹林治疗妊娠期高血压疾病不仅能改善微环境炎症及血管内皮功能,提高血压控制效果,还能减少不良妊娠结局发生,值得临床进一步推广及应用。
Objective To analyze the effect of urapidil combined with magnesium sulfate and aspirin in the treatment of hypertensive disorder complicating pregnancy and its influence on microenvironment inflammation.Methods A total of 80 patients with hypertensive disorder complicating pregnancy admitted in our hospital from January 2021 to March 2022 were selected as the research objects,and the patients were divided into control group and observation group by random number table method,with 40 cases in each group.The control group was treated with magnesium sulfate and aspirin,and the observation group was treated with urapidil on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the systolic blood pressure,diastolic blood pressure and urinary protein content in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of soluble interleukin 2 receptor(sIL-2R),nuclear factor-κB(NF-κB)and high mobility group box 1(HMGB1)in the observation group were lower than those in the control group(P<0.05).After treatment,the level of endothelin-1(ET-1)in the observation group was lower than that in the control group,and the levels of vascular endothelial growth factor(VEGF)and platelet endothelium cell adhesion molecules-1(PECAM-1)were higher than those in the control group(P<0.05).The total incidence of adverse pregnancy in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Urapidil combined with magnesium sulfate and aspirin in the treatment of hypertensive disorder complicating pregnancy can not only improve the microenvironment inflammation and vascular endothelial function,improve the effect of blood pressure control,but also reduce the occurrence of adverse pregnancy outcomes,which is worthy of further clinical promotion and application.
作者
王彩梅
刘继梅
寇帅
WANG Caimei;LIU Jimei;KOU Shuai(Yulin No.2 Hospital,Yulin 719000,China)
出处
《临床医学研究与实践》
2024年第1期124-127,136,共5页
Clinical Research and Practice
关键词
乌拉地尔
硫酸镁
阿司匹林
妊娠期高血压疾病
微环境炎症
妊娠结局
urapidil
magnesium sulfate
aspirin
hypertensive disorder complicating pregnancy
microenvironment inflammation
pregnancy outcome
