摘要
目的探讨血清白介素-6(IL-6)、降钙素原(PCT)、C-反应蛋白(CRP)及白细胞计数(WBC)在老年腹部手术患者术后早期肺部感染的诊断价值。方法选取汝阳县人民医院2022年5月至2023年5月收治的80例老年腹部手术患者为研究对象,根据术后肺部感染情况分为感染组(n=27)、未感染组(n=53);对比两组术前及术后6 h、术后24 h、术后72 h时血清IL-6、PCT、CRP、WBC水平;受试者工作特征(ROC)曲线分析术后24 h血清各指标联合检测对老年腹部手术患者术后并发早期肺部感染的诊断价值;根据肺部感染(CPIS)评分评估患者感染程度;对比不同程度感染患者术后24 h、术后72 h时血清各指标水平;分析术后24 h血清各指标与肺部感染(CPIS)评分的相关性。结果感染组术后6 h、术后24 h、术后72 h时血清IL-6、PCT、CRP、WBC水平高于未感染组,差异均有统计学意义(P<0.05);术后24 h血清IL-6、PCT、CRP、WBC水平联合诊断老年腹部手术患者术后发生肺部感染的曲线下面积(AUC)为0.882;重度感染患者术后24 h、72 h时血清IL-6、PCT、CRP、WBC水平均高于轻度感染患者,差异均有统计学意义(P<0.05);感染组术后24 h血清IL-6、PCT、CRP、WBC与CPIS评分均呈正相关,差异具有统计学意义(P<0.05)。结论血清IL-6、PCT、CRP、WBC水平与腹部手术患者术后早期肺部感染密切相关,其水平对临床诊断术后患者早期肺部感染具有重要价值。
Objective To investigate the diagnostic value of serum interleukin-6(IL-6),procalcitonin(PCT),C-reactive protein(CRP),and white blood cell count(WBC)in the early diagnosis of postoperative pulmonary infection in elderly patients undergoing abdominal surgery.Methods A total of 80 elderly abdominal surgery patients admitted to Ruyang County People's Hospital from May 2022 to May 2023 were selected as the research subjects,and they were divided into an infection group(n=27)and a non-infection group(n=53)according to the postoperative lung infection status.Compare the levels of serum IL-6,PCT,CRP,and WBC in the two groups before and after surgery at 6 hours,24 hours,and 72 hours;analyze the diagnostic value of combined detection of serum indicators at 24 hours after surgery for early postoperative pulmonary infection in elderly patients undergoing abdominal surgery using ROC analysis;assess the infection severity of patients based on the CPIS score;compare the levels of serum indicators in patients with different degrees of infection at 24 hours and 72 hours after surgery;and analyze the correlation between serum indicators at 24 hours after surgery and CPIS score.Results The levels of IL-6,PCT,CRP and WBC in infected group were higher than those in uninfected group at 6 hours,24 hours and 72 hours after operation,and the differences were statistically significant(P<0.05).The AUC level of serum IL-6,PCT,CRP and WBC at 24 hours after surgery for combined diagnosis of postoperative pulmonary infection in elderly patients with abdominal surgery was 0.882.The levels of IL-6,PCT,CRP and WBC in patients with severe infection were higher than those in patients with mild infection at 24 hours and 72 hours after surgery,with statistical significance(P<0.05).Serum IL-6,PCT,CRP,WBC were positively correlated with CPIS score 24h after infection,with statistical significance(P<0.05).Conclusion Serum IL-6,PCT,CRP and WBC levels are closely related to early postoperative lung infection in patients with abdominal surgery,which is of great significance for clinical diagnosis of early postoperative lung infection.
作者
高相丽
王克洛
GAO Xiangli;WANG Keluo(Department of Laboratory Medicine,Ruyang County People's Hospital,Luoyang Henan 471200,China)
出处
《临床研究》
2024年第1期133-136,共4页
Clinical Research
