摘要
新生儿化脓性脑膜炎(NPM)是新生儿常见的中枢神经系统感染性疾病,临床表现特异性差,通常表现为嗜睡、烦躁、厌食、腹泻等,早期诊断困难,具有较高的发病率、致残率和致死率。其中B族链球菌、大肠埃希菌感染的脑膜炎对新生儿生命具有潜在威胁,可迅速进展为脑损害,甚至危及生命。因此,早期诊断及早期治疗对减少NPM造成的并发症及后遗症有重要作用。通过对NPM流行病学趋势、实验室检查新进展及影像学表现等进行综合分析,特别是对脑脊液细胞因子检测的研究,为辅助NPM的早期诊断提供了事实依据,能最大程度减少并发症,降低致残率,甚至死亡率,从而改善患儿预后,提高患儿生活质量。本研究在梳理NPM的流行病学特点、诊断标准、实验室检测指标、影像学检查等方面的基础上,主要综述细胞因子检测在NPM中的意义,以期为NPM的诊断及治疗提供辅助依据。
Neonatal purulent meningitis(NPM)is a common central nervous system infection in neonates.The clinical manifestations are not specific,usually manifested as lethargy,irritability,anorexia,diarrhea,etc.It is difficult to diagnose in the early stage and has high morbidity,disability and mortality.Meningitis infected by Group B streptococcus and Escherichia coli is a potential threat to newborn lives,which can rapidly progress to brain damage and even life-threatening.Therefore,early diagnosis and early treatment play an important role in reducing the complications and sequelae of NPM.The comprehensive analysis of epidemiological trends,new advances in laboratory examinations and imaging manifestations,especially the detection of cerebrospinal fluid cytokine,provide a factual basis for the early diagnosis of NPM,which can help tominimize complications,reduce the disability rate,and improve the prognosis and quality of life of the patient.On the basis of reviewing the epidemiological characteristics,diagnostic criteria,laboratory test indexes and imaging examination of NPM,this study reviews the significance of cerebrospinal fluid cytokine detection in NPM,in order to provide an auxiliary basis for the diagnosis and treatment of NPM.
作者
刘迪
赵晓芬
LIU Di;ZHAO Xiaofen(Kunming Children′s Hospital,Yunnan Kunming 650228,China)
出处
《中国医药导刊》
2023年第9期898-902,共5页
Chinese Journal of Medicinal Guide
基金
昆明市卫生科技人才培养项目[项目编号:2021-SW(省)-22,项目名称:脑脊液细胞因子在新生儿化脓性脑膜炎中的诊断作用]。
