摘要
随着我国泽泻药材主流商品的重大变化,亟待建立川泽泻药材商品规格等级标准。本文将42批川泽泻药材商品初步划分为73组,量化测定其潜在分级指标,包括单个重、长度、直径、粉末色度值(L^(*)、a^(*)、b^(*))等外观性状指标,及浸出物、3种三萜类药效成分(23-乙酰泽泻醇B、23-乙酰泽泻醇C和泽泻醇B)、总三萜、总多糖的含量等内在物质基础指标。综合运用描述统计法、方差分析法、熵权法、灰色关联度法、相关性分析法对测定数据开展多元计量学分析,筛选出单个重、长度、3种三萜类成分总含量作为川泽泻药材商品的等级划分指标。以K-均值聚类分析法初步拟定川泽泻商品等级标准为:一等品单个重≥25 g,长度5.5~7.0 cm,3种三萜类成分总含量≥0.6%;二等品单个重15~25 g,长度4.0~5.5 cm,3种三萜类成分总含量0.4%~0.6%;统货单个重≥10 g,长度2.0~7.0 cm,3种三萜类成分总含量≥0.2%。综上所述,本研究筛选出川泽泻商品等级划分的科学指标,并拟订川泽泻药材商品等级标准(草案),有利于促进商品市场泽泻药材实现“优质优价”。
With the major changes in the mainstream commodities of Alismatis Rhizoma in China,it is urgent to establish the specification and grade standards of Sichuan Alismatis Rhizoma.In this paper,42 batches of Alismatis Rhizoma are preliminarily didided into 73 groups.and their potential grading indicators were quantitatively determined,including individual weight,length,diameter,powder color value(L^(*),a^(*),b^(*))and other appearance traits,as well as intrinsic material base indicators such as extractables,three triterpenoid pharmacodynamic components(23-acetyl alisol B,23-acetyl alisol C and alisol C),total triterpenoids,and total polysaccharide content.The descriptive statistical method,analysis of variance method,entropy weight method,gray correlation degree method and correlation analysis method were comprehensively used to carry out multi-econometric analysis of the measured data,and the total content of a single weight,length and three triterpenoid components were screened out as the grade classification indicators of Alismatis Rhizoma.The K-means cluster analysis method was used to preliminarily formulate the grade standards of Alismatis Rhizoma commodities as follows:The single weight of first grade was≥25 g,the length was 5.5-7.0 cm,and the total content of three triterpenoids was≥0.6%;The single weight of second grade was 15-25 g,the length was 4.0-5.5 cm,and the total content of three triterpenoids was 0.4%-0.6%.The single weight of ungraded goods was≥10 g,the length was 2.0-7.0 cm,the total content of three triterpenoids was≥0.2%.In summary,this study screened out the scientific indicators of the classification of Alismatis Rhizoma commodities,and formulated the commodity grade standards(draft)of Alismatis Rhizoma,which is conducive to promoting the realization of"high quality and high price"of Alismatis Rhizoma in the commodity market.
作者
赵璐璐
先蕊
赵文琪
郑雯
兰志琼
潘晓丽
李敏
ZHAO Lu-lu;XIAN Rui;ZHAO Wen-qi;ZHENG Wen;LAN Zhi-qiong;PAN Xiao-li;LI Min(State Key Laboratory of Southwestern Chinese Medicine Resources,School of Pharmacy/College of Modern Chinese Medicine Industry,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)
出处
《天然产物研究与开发》
CAS
CSCD
2023年第12期2094-2107,共14页
Natural Product Research and Development
基金
成都中医药大学“杏林学者”学科人才科研提升计划(XCZX2022006)
四川省科技厅项目-中药材及相关制剂外源性污染物快速检测技术研究(2020YFS0303)
国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人函[2019]41号)。
关键词
川泽泻
商品等级
性状
内在品质
多元计量法
泽泻醇B
Alismatis Rhizoma
commercial grades
characters
intrinsic quality
multi-metrology method
alisol B
