摘要
目的 比较酮咯酸氨丁三醇与氢溴酸山莨菪碱在输尿管结石导致的急性肾绞痛患者中的应用效果。方法 回顾性分析2020年1月至2022年1月于北京市海淀医院急诊外科就诊的166例输尿管结石导致的急性肾绞痛患者的临床资料,采用随机数字法将研究对象分为对照组(肌内注射氢溴酸山莨菪碱,81例)和观察组(肌内注射酮咯酸氨丁三醇,85例)。比较分析两组患者用药前以及用药后30 min、1 h、4 h的疼痛程度,用药后30 min的临床疗效,用药期间的不良反应发生情况。结果 与用药前比较,两组患者用药后30 min、1 h、4 h的视觉模拟评分法(VAS)评分均降低,差异均有统计学意义(P<0.05)。用药前,两组患者的VAS评分比较差异无统计学意义(P>0.05);用药后30 min、1 h、4 h,观察组患者的VAS评分均低于对照组,差异均有统计学意义(P<0.05)。用药后30 min,观察组患者的总有效率高于对照组,差异有统计学意义(P<0.05)。观察组患者用药期间的不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论 在输尿管结石导致的急性肾绞痛患者中,与肌内注射氢溴酸山莨菪碱比较,肌内注射酮咯酸氨丁三醇的镇痛效果更好,且不良反应更少。
Objective To compare the application effects of ketorolac aminotroamine and anisodamine hydrobromide in patients with acute renal colic caused by ureteral calculi.Method The clinical data of 166 patients with acute renal colic caused by ureteral calculi treated in the emergency surgery department of Beijing Haidian Hospital from January 2020 to January 2022 were retrospectively analyzed.The study subjects were divided into control group(81 cases with intramuscular injection of anisodamine hydrobromide)and observation group(85 cases with intramuscular injection of ketorolac tromethamine)by random number method.The pain degree before medication and 30 min,1 h and 4 h after medication,clinical effect 30 min after medication,the occurrence of adverse reactions during medication were compared and analyzed between the two groups.Result Compared with before medication,the VAS scores of two groups were decreased 30 min,1 h and 4 h after medication,and the differences were significant(P<0.05).Before medication,there was no significant difference in VAS scores between two groups(P>0.05).The VAS scores of observation group were lower than those of control group 30 min,1 h and 4 h after treatment,and the differences were significant(P<0.05).30 min after treatment,the total effective rate of observation group was higher than that of control group,and the difference was significant(P<0.05).The incidence of adverse reactions in observation group was lower than that of control group,and the difference was significant(P<0.05).Conclusion In patients with acute renal colic caused by ureteral calculi,intramuscular injection of ketorolac tromethamine has better analgesic effect than intramuscular injection of anisodamine hydrobromide,with lower incidence of adverse reactions.
作者
杜剑
孔蕊红
左永波
陈庆军
Du Jian;Kong Ruihong;Zuo Yongbo;Chen Qingjun(Department of Emergency Surgrey,Beijing Haidian Hospital,Beijing 100080,China;Department of Emergency Surgrey,Beijing Hepingli Hospital,Beijing 100013,China)
出处
《中国医刊》
CAS
2024年第1期83-85,共3页
Chinese Journal of Medicine
