摘要
综述中药单体靶向哺乳动物雷帕霉素靶蛋白(mTOR)治疗肺癌的研究进展。mTOR是一种重要的细胞信号通路,参与调控细胞生长、增殖和存活等过程;在肺癌中,mTOR信号通路的异常活化与肿瘤的发生和发展密切相关。研究发现,许多中药单体成分(萜类、黄酮类、生物碱类、多酚类、醌类等)具有抑制mTOR信号通路的作用,为开发肺癌新药提供了前期基础。
Research progress on traditional Chinese medicinal monomers targeting mammalian rapamycin target protein(mTOR)in the treatment of lung cancer is reviewed.mTOR,an essential cellular signaling pathway,is involved in regulating processes such as cell growth,proliferation,and survival.In lung cancer,the abnormal activation of the mTOR signaling pathway is closely associated with the initiation and progression of tumors.Studies have found that many traditional Chinese medicinal monomeric components(terpenes,flavonoids,alkaloids,polyphenols,quinones,etc.)possess the ability to inhibit the mTOR signaling pathway,laying a preliminary foundation for the development of new drugs for lung cancer.
作者
朱丽华
管思思
刘吟絮
黄弦歌
陆恩昊
吴冠中
李和根
ZHU Lihua;GUAN Sisi;LIU Yinxu;HUANG Xian´ge;LU Enhao;WU Guanzhong;LI Hegen(Department of Oncology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)
出处
《上海中医药杂志》
CSCD
2024年第1期31-37,共7页
Shanghai Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(82205214)
上海市科委中医肿瘤临床医学研究中心项目(21MC1930500)
上海市卫健委李和根名老中医学术经验研究工作室项目(SHGZS-202215)。
关键词
肺癌
哺乳动物雷帕霉素靶蛋白
中药单体
研究进展
lung cancer
mTOR
traditional Chinese medicinal monomeric components
research progress
