摘要
结直肠癌(CRC)是我国发病率和死亡率较高的消化道恶性疾病之一,“微生物-脑-肠轴”包括肠道菌群微生物及其代谢产物、肠神经系统、自主神经系统、神经免疫学、神经内分泌系统和中枢神经系统,“微生物-脑-肠轴”在CRC肿瘤细胞的生长、增殖、侵袭和转移方面起重要作用。中医药凭借中医思维优势,以中医整体观认识CRC,脑肠同治,在脑-心-神及肠-脾-肝2个方面对机体进行调节,维持“微生物-脑-肠轴”的相对平衡,进而防治结直肠癌。
Colorectal cancer(CRC)is one of the malignant diseases of the digestive tract,with high morbidity and mortality in China.The microorganism-gut-brain axis includes gut flora and their metabolites,enteric nervous system,autonomic nervous system,neuroimmune system,neuroendocrine system,and central nervous system.It plays an important role in the growth,proliferation,invasion,and metastasis of CRC cells.According to the holistic view of traditional Chinese medicine(TCM),CRC can be treated from both the brain and the gut.The balance of the microorganism-gut-brain axis can be maintained by regulating the intestinal flora,which can inhibit the progression of CRC.
作者
王欣妍
王烁
曹康迪
樊芬
侯炜
WANG Xinyan;WANG Shuo;CAO Kangdi;FAN Fen;HOU Wei(Graduate School,Beijing University of Chinese Medicine,Beijing 100029,China;Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)
出处
《世界中医药》
CAS
2023年第21期3085-3089,共5页
World Chinese Medicine
基金
国家自然科学基金项目(8207142125)
中国中医科学院科技创新工程重大攻关项目(CI2021A01801)。
关键词
结直肠癌
肠道菌群
脑-肠轴
脑肠同治
中医药
分期治疗
癌前病变
微生物
Colorectal cancer
Intestinal flora
Brain-gut axis
Simultaneous treatment of brain and gut
Traditional Chinese medicine
Staging treatment
Precancerous lesions
Microorganisms
