摘要
通过静电纺丝法制备出负载非笛体抗炎药美洛昔康(MLX)的聚己内酯(PCL)纳米纤维。红外光谱结果表明复合纤维中的MLX和PCL之间形成了氢键。负载MLX后纤维形貌良好,粗细均匀,接触角从58.2°上升到110.9°,吸水率从41.36%下降到24.51%,表明其疏水性能增强。纤维的拉伸断裂强度从1.5MPa降到0.13MPa,表明其力学性能有所下降。药物的体外溶出实验结果表明,纤维释药接近完全的时间均在2h以内。结合Korsmeyer-Peppas模型和MLX/PCL药物释放前后的纤维形貌变化来评价PCL/MLX纤维膜的药物释放模型,结果表明其机理属于非Fick扩散释放,符合以扩散和骨架溶蚀共存的药物释放方式。
Polycaprolactone(PCL)nanofibers loaded with nonsteroidal anti-inflammatory drug meloxicam(MLX)were prepared by electrospinning.The infrared spectroscopy results indicate the formation of hydrogen bonds between MLX and PCL in the composite fibers.After loading MLX,the morphology of the fibers is good,with uniform thickness.The contact angle increases from 58.2°to 110.9°,and the water absorption decreases from 41.36%to 24.51%,indicating an enhanced hydrophobicity.The tensile fracture strength of the fiber decreased from 1.5MPa to 0.13MPa,indicating a decrease in its mechanical properties.The in vitro dissolution test results of the drug showed that the nearly complete release time of the fiber drug was within 2 hours.The drug release model of PCL/MLX fiber membrane was evaluated by combining the Korsmeyer Peppas model and the changes in fiber morphology before and after drug release of MLX/PCL.The results showed that its mechanism belongs to non Fick diffusion release,which conforms to the drug release mode of coexistence of diffusion and skeleton dissolution.
作者
张进
兰龙宇
陈越军
刘春杰
吴振刚
魏恒勇
ZANG Jin;LAN Long-yu;CHEN Yue-jun;LIU Chun-jie;WU Zhen-gang;WEI Heng-yong(College of Pharmacy,Noth China University of Science and Technology,Tangshan 063210 China;College of Materials Science and Engineering,North China University of Science and Technology,Tangshan 063210 China;.3.Hebei Provincial Key Laboratory of Inorganic and Non metallie Materials,North China University of Science and Technology,Tangshan 063210 China;Tangshan Workers Hospital,Tangshan 063210 China)
出处
《化学研究与应用》
CAS
北大核心
2023年第12期2967-2974,共8页
Chemical Research and Application
基金
河北省自然科学基金项目(H2020105015)资助
河北省博士后科研项目择优资助项目(B2021003045)资助
河北省“三三三人才工程”资助项目(A202101133)资助
华北理工大学大学生创新创业训练计划项目(R2020038)资助。
