摘要
甲状腺功能异常患者的凝血指标可出现异常,存在潜在发生血栓或出血的风险。甲状腺功能亢进患者存在显著的血管内皮功能紊乱并引起血栓风险,但关于甲状腺功能减退对凝血功能的影响仍存在争议。甲状腺功能异常对凝血系统的潜在风险可能干扰抗凝药物治疗安全性,同时甲状腺疾病治疗药物与抗凝药物之间的相互作用也对患者的用药安全造成影响。该文基于既往研究文献分析甲状腺功能异常与凝血功能相关性,评估和探讨甲状腺功能异常对凝血系统的影响及相关治疗药物相互作用,以期为甲状腺功能紊乱合并凝血功能异常患者的诊治提供参考。
For patients with abnormal thyroid function,the detection of peripheral blood coagulation indicators may be irregular,and there is a potential risk of thrombosis or bleeding.Patients with hyperthyroidism have significant endothelial dysfunction and risk of thrombosis.However,the reports on the effect of hypothyroidism on coagulation function are still controversial.The potential risk of abnormal thyroid function to the coagulation system may interfere with the safety of anticoagulant therapy,and the interaction between thyroid disease treatment drugs and anticoagulant drugs also affects the safety of the patient's medication.Therefore,this article is based on previous research literature,analyzes the correlation between abnormal thyroid function and coagulation function,and evaluates and discusses the impact of abnormal thyroid function on the coagulation system and related therapeutic drug interactions.It is expected to provide a reference for diagnosing and treating patients with thyroid dysfunction and abnormal coagulation function.
作者
蒋敏
边原
龙恩武
JIANG Min;BIAN Yuan;LONG Enwu(Department of Pharmacy,West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu 610041,China;Personalized Drug Therapy Key Laboratory of Sichuan Province,Department of Pharmacy,Sichuan Academy of Medical Sciences,Sichuan Provincial People's Hospital,the Affiliated Hospital of University of Electronic Science and Technology of China,Chengdu 610072,China)
出处
《医药导报》
CAS
2024年第1期85-90,共6页
Herald of Medicine
基金
国家重点研发计划(2020YFC2005506)
个体化药物治疗四川省重点实验室开放课题(2021Z001)
四川省干部保健科研课题(川干研2021-226)
四川省科技厅自然科学基金资助项目(2022NSFSC0818)。
