摘要
目的观察益脑康胶囊(天麻、胆南星、全蝎等)联合盐酸多奈哌齐片治疗卒中后认知障碍(PSCI)的临床疗效。方法纳入门诊符合PSCI诊断标准的患者110例,按照随机数字表法将患者分为试验组和对照组,每组各55例。对照组患者予西医常规治疗,包括盐酸多奈哌齐片治疗,以及降血压、降血脂、降血糖、抗血小板聚集等脑卒中二级预防处理;试验组在对照组基础上给予益脑康胶囊治疗,两组均治疗6个月。治疗前和治疗6个月后分别采用蒙特利尔认知评估(MoCA)量表评估患者的认知功能,日常生活能力(ADL)量表评估患者日常生活能力,脑白质病变严重程度的视觉评分(Fazekas)量表评估患者脑白质病变程度,并观察患者的不良反应。结果治疗6个月后,两组患者MoCA评分总分、MoCA分项中视空间与执行功能评分、注意力评分、延迟回忆评分及ADL评分总分均较治疗前有改善(P<0.05),且试验组改善程度优于对照组(P<0.05);试验组治疗后Fazekas评分较治疗前无显著性差异(P>0.05),对照组治疗后Fazekas评分较治疗前增加(P<0.05),且试验组延缓脑白质病变作用优于对照组(P<0.05)。结论益脑康胶囊联合盐酸多奈哌齐片治疗PSCI效果优于盐酸多奈哌齐单药治疗,能有效地改善患者的认知功能及日常生活能力,并能延缓脑白质病变进展。
Objective To observe the clinical effect of Yi'naokang Capsules combined with Donepezil Hydrochloride Tablets in treating post-stroke cognitive impairment(PSCI).Methods 110 patients who met the diagnostic criteria of PSCI in the outpatient department were included.According to the random number table method,the patients were divided into trial group and control group,with 55 cases in each group.Patients in control group were treated with routine western medicine,including the treatment of Donepezil Hydrochloride Tablets and secondary prevention of stroke such as lowering blood pressure,lowering blood lipid,lowering blood glucose and anti-platelet aggregation.The trial group was treated with Yi'naokang Capsules on the basis of the treatment in control group.and both groups were treated for 6 months.Before and after 6 months of treatment,the cognitive function of patients was evaluated by the Montreal Cognitive Assessmentt(MoCA)scale.The activity of daily living(ADLs)cale was used to evaluate the ability of daily living,and the severity of cerebral white matter lesions was evaluated by Fazekas scale,and the adverse reactions were also observed.Results After 6 months of treatment,the total score of the MoCA,the scores of visual space and executive function,attention,delayed recall and the ADL of the two groups were al improved(P<0.05),and the improvement degree of the trial group was better than that of the control group(P<0.05).The Fazekas score of the trial group after treatment was no significant difference when compared with that before treatment(P>0.05),but it increased in the control group after treatment(P<0.05),and the effect of delaying white matter lesion in the trial group was better than that in the control group(P<0.05).Conclusion Yi'naokang Capsules combined with Donepezil Hydrochloride Tablets are superior to Donepezil alone in the treatment of PSCI,which can safely and effectively improve the cognitive function and daily living ability of patients,as well as prolong the progress of white matter lesions.
作者
陈岱宜
廖惠娟
严浩荣
刘启亮
梁荣坚
孙景波
CHEN Daiyi;LIAO Huijuan;YAN Haorong;LIU Qiliang;LIANG Rongjian;SUN Jingbo(The Second Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 510006 Guangdong,China;State Key Laboratory of Dampness Syndrome of Traditional Chinese Medicine,The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120 Guangdong,China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2023年第12期1793-1798,共6页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家科技重点研发计划课题(2019YFC1708601)
广州中医药大学“双一流”与高水平大学学科协同创新团队培育项目(2021xk84)
广州市科技计划项目(202102010339)
广东省中医院中医药科技专项(YN2018ZD04)。
关键词
益脑康胶囊
盐酸多奈哌齐片
卒中后认知障碍
认知功能
脑白质病变
临床疗效
Yin'aokang Capsules
Donepezil Hydrochloride Tablets
cognitive impairment after stroke
cognitive function
cerebral white matter lesions
clinical effect
