摘要
目的探究纤维蛋白原/前白蛋白比值(FPR)与初诊多发性骨髓瘤(MM)患者预后的关系。方法回顾性分析2015年1月-2022年1月安徽医科大学附属巢湖医院和安徽医科大学第一附属医院初诊MM患者100例,收集患者临床资料,通过受试者工作特征曲线(ROC)计算出FPR最佳截断值。按照FPR最佳截断值将患者分为高FPR组(56例)和低FPR组(44例)。比较两组总生存时间(OS)和无进展生存时间(PFS),并对影响初诊多发性骨髓瘤患者疾病进展的危险因素进行单因素和多因素分析。结果ROC曲线的最佳截断值为0.0168。高FPR组与低FPR组间ISS分期、β2-MG、血红蛋白、血清钙、骨髓浆细胞比例及分型比较,差异有统计学意义(P<0.05)。单因素分析显示,ISS分期、FPR、白蛋白、骨髓浆细胞比例及4个疗程后疗效是初诊MM患者OS和PFS的影响因素(P<0.05)。多因素分析显示,ISS分期、FPR、白蛋白、4个疗程后疗效是初诊MM患者PFS独立危险因素(P<0.05)。ISS分期、FPR、白蛋白、骨髓浆细胞比例及4个疗程后疗效是初诊MM患者OS的独立危险因素(P<0.05)。结论FPR是影响初诊MM患者OS的独立危险因素,高FPR提示预后不良。
Objective To investigate the relationship between fibrinogen/pre-albumin ratio(FPR)and prognosis of patients with newly diagnosed multiple myeloma(MM).Methods A retrospective analysis of 100 newly diagnosed MM patients in Chaohu Hospital of Anhui Medical University and the First Affiliated Hospital of Anhui Medical University from January 2015 to January 2022 was performed.The clinical data of the patients were collected,and the best cut-off value of FPR was calculated by the receiver operating characteristic curve(ROC).According to the optimal cut-off value of FPR,the patients were divided into high FPR group(56 patients)and low FPR group(44 patients).The overall survival time(OS)and progression-free survival time(PFS)were compared between the two groups,and the risk factors affecting the disease progression of newly diagnosed multiple myeloma patients were analyzed by univariate and multivariate analysis.Results The best cut-off value of ROC curve was 0.0168.There were significant differences in ISS stage,β2-MG,hemoglobin,serum calcium,bone marrow plasma cell ratio and classification between high FPR group and low FPR group(P<0.05).Univariate analysis showed that ISS stage,FPR,albumin,bone marrow plasma cell ratio and efficacy after 4 courses of treatment were the influencing factors of OS and PFS in newly diagnosed MM patients(P<0.05).Multivariate analysis showed that ISS stage,FPR,albumin,and efficacy after 4 courses of treatment were independent risk factors for PFS in newly diagnosed MM patients(P<0.05).ISS stage,FPR,albumin,bone marrow plasma cell ratio and efficacy after 4 courses of treatment were independent risk factors for OS in newly diagnosed MM patients(P<0.05).Conclusion FPR is an independent risk factor affecting OS in newly diagnosed MM patients,and high FPR indicates poor prognosis.
作者
刘北
夏海龙
焦燕
张慧敏
LIU Bei;XIA Hai-long;JIAO Yan;ZHANG Hui-min(Department of Hematology,Chaohu Hospital of Anhui Medical University,Chaohu 238000,Anhui,China;Department of Hematology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui,China)
出处
《医学信息》
2024年第1期130-134,共5页
Journal of Medical Information
