摘要
目的:探究血管生成抑制蛋白1(VASH-1)、血清沉默信息调节因子1(Sirt1)与血栓素-B2(TXB2)在2型糖尿病肾病中的水平变化及与白蛋白尿进展的关系。方法:选取198例2型糖尿病肾病患者纳入研究组,另选100例无肾脏损害的2型糖尿病患者为对照组,对患者进行随访,检测记录患者的血清VASH-1、Sirt1、TXB2水平,并根据患者是否发生白蛋白尿分层研究,分析VASH-1、Sirt1、TXB2水平与患者白蛋白尿进展的关系。结果:与对照组比较,研究组患者的血清VASH-1、Sirt1水平降低,TXB2水平升高(均P<0.05)。与进展组患者相比较,维持组患者的血清VASH-1、Sirt1水平升高,TXB2水平降低(均P<0.05)。进展组和维持组患者的空腹血糖(FPG)、餐后2h血糖(2hPG)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)水平比较差异无统计学意义(均P>0.05)。以研究组患者是否发生白蛋白尿进展为因变量,以患者的血清VASH-1、Sirt1、TXB2水平为自变量,进行多因素Logistic回归分析,可知血清VASH-1、Sirt1、TXB2水平均会对患者发生白蛋白尿进展产生影响(均P<0.05)。采用ROC曲线探究2型糖尿病肾病患者血清VASH-1、Sirt1、TXB2水平对白蛋白尿进展的预测价值,其AUC值分别为0.943、0.758、0.894(均P<0.05)。结论:2型糖尿病肾病患者的血清VASH-1和Sirt1的水平下降,TXB2的水平上升,其水平变化与白蛋白尿的进展有关,对糖尿病肾病患者发生白蛋白尿进展具有一定预测价值。
Objective:To i nvestigate the changes of the levels of vascular endothelial growth inhibitor 1(VASH-1),serum silence-message regulator 1(Sirt1)and thromboxin-B 2(TXB 2)in type 2 diabetic nephropathy and their relationship with albuminuria progression.Methods:A total of 198 patients with type 2 diabetic nephropathy who received treatment were included in the study group,and 100 patients with type 2 diabetes were selected as the control group.The patients were followed up,the levels of VASH-1,Sirt1 and TXB 2 in patients were detected and recorded,and the relationship between the levels of VASH-1,Sirt1 and TXB 2 and the progression of albuminuria in patients was analyzed according to whether the patients developed albuminuria.Results:Compared with the control group,the levels of VASH-1 and Sirt1 in the study group were decreased,and the levels of TXB 2 were increased(all P<0.05).Compared with the progressive group,the levels of VASH-1 and Sirt1 in the maintenance group were increased,and the levels of TXB 2 were decreased(all P<0.05).There was no significant difference in the levels of FPG,2 hPG,FINS,HbA1c and HOMA-IRbetween the progressive group and the maintenance group(all P>0.05).With the progression of albuminuria in the study group as the dependent variable and the levels of VASH-1,Sirt1,TXB 2 and HOMA-IRof the patients as the independent variables,multivariate Logistic regression analysis showed that serum levels of VASH-1,Sirt1,and TXB 2 would have an impact on the progression of albuminuria in the patients(all P<0.05).ROC curve was used to investigate the predictive value of serum VASH-1,Sirt1 and TXB 2 albuminuria progression in diabetic nephropathy patients,and the AUC values were 0.943,0.758 and 0.894,respectively(all P<0.05).Conclusion:The levels of VASH-1 and Sirt1 decreased and the levels of TXB 2 increased in patients with type 2 diabetic nephropathy.The changes of VASH-1 and SIRT1 were correlated with the progression of albuminuria,which had certain predictive value for the progression of albuminuria in patients with diabetic nephropathy.
作者
蒋琳
陆璧
张彦
李梦婷
JIANG Lin;LU Bi;ZHANG Yan;LI Mengting(Department of Endocrinology,Zhangjiagang Aoyang Hospital,Zhangjiagang 215600,China)
出处
《陕西医学杂志》
CAS
2024年第1期46-50,共5页
Shaanxi Medical Journal
基金
江苏省自然科学基金资助面上项目(BK20211130)。
