摘要
目的:分析血清γ-谷氨酰转移酶(GGT)、总胆红素(TBIL)、三酰甘油(TG)水平联合检测对胆囊结石合并胆总管结石患者术后胆总管结石复发的预测价值。方法:选取2019年10月至2021年12月于该院行手术治疗的169例胆囊结石合并胆总管结石患者进行前瞻性研究。术后随访1年,根据胆总管结石是否复发将其分为复发组(n=48)和未复发组(n=121)。比较两组术前及术后3、6个月血清GGT、TBIL、TG水平,并分析血清GGT、TBIL、TG水平单项及联合检测预测胆总管结石复发的价值。结果:术后3、6个月,复发组血清GGT、TBIL、TG水平均高于未复发组,差异有统计学意义(P<0.05);术后3个月,血清GGT、TBIL、TG水平单项及联合检测预测胆总管结石复发的曲线下面积(AUC)分别为0.765、0.720、0.751、0.895,均具有一定预测价值,其中联合检测预测价值最高;术后6个月,血清GGT、TBIL、TG水平单项及联合检测预测胆总管结石复发的AUC分别为0.798、0.735、0.771、0.916,均具有一定预测价值,其中联合检测预测效能最高,且术后6个月联合检测预测价值高于术后3个月联合检测预测价值。结论:血清GGT、TBIL、TG水平联合检测预测胆总管结石复发的价值高于三者单项检测预测价值,且术后6个月联合检测预测价值高于术后3个月联合检测预测价值。
Objective:To analyze value of combined detection of serumγ-glutamyl transferase(GGT),total bilirubin(TBIL)and triglyceride(TG)levels in prediction of postoperative recurrence of choledocholithiasis in patients with cholecystolithiasis and choledocholithiasis.Methods:A prospective study was conducted on 169 patients with cholecystolithiasis and choledocholithiasis who underwent surgical treatment in this hospital from October 2019 to December 2021.These patients were followed up for 1 year.According to the recurrence of choledocholithiasis,they were divided into recurrence group(n=48)and non-recurrence group(n=121).The levels of serum GGT,TBIL and TG were compared between the two groups before as well as 3 and 6 months after the surgery.The values of single and combined detection of serum GGT,TBIL and TG levels in the prediction of the recurrence of choledocholithiasis were analyzed.Results:3 and 6 months after the surgery,the levels of serum GGT,TBIL and TG in the recurrence group were higher than those in the non-recurrence group,and the differences were statistically significant(P<0.05).After 3 months of treatment,the areas under the curve(AUCs)of single and combined detection of serum GGT,TBIL and TG levels in the prediction of recurrence of choledocholithiasis were 0.765,0.720,0.751 and 0.895,separately,all of which had certain predictive value,and the combined detection had the highest predictive value.After 6 months of treatment,the AUCs of single and combined of serum GGT,TBIL and TG levels in the prediction of recurrence of choledocholithiasis were 0.798,0.735,0.771 and 0.916,separately,all of which had certain predictive value,and the combined detection had the highest predictive efficiency.The predictive value of combined detection 6 months after the treatment was higher than that of combined detection 3 months after the treatment.Conclusions:The value of combined detection of serum GGT,TBIL and TG levels in the prediction of the recurrence of choledocholithiasis is higher than that of single detection of the three,and the predictive value of combined detection a6 months after the treatment is higher than that of combined detection 3 months after the treatment.
作者
冯利得
张刚强
苏九明
FENG Lide;ZHANG Gangqiang;SU Jiuming(Department of Clinical Laboratory of Anyang Hospital of Traditional Chinese Medicine,Anyang 455000 Henan,China)
出处
《中国民康医学》
2023年第24期133-136,共4页
Medical Journal of Chinese People’s Health
关键词
胆囊结石
胆总管结石
Γ-谷氨酰转移酶
总胆红素
三酰甘油
Cholecystolithiasis
Choledocholithiasis
γ-glutamyl transferase
Total bilirubin
Triacylglycerol
