摘要
溃疡性结肠炎(ulcerative colitis,UC)是一种病因尚不十分明确的结肠和直肠慢性非特异性疾病。UC与肠道免疫关系密切,肠相关淋巴组织以及固有层含有丰富的免疫细胞,对于维持肠道免疫稳态具有重要作用。辅助性T细胞(T helper cell, Th)17/调节性T细胞(T regulatory cell, Treg)失衡与UC肠道免疫稳态息息相关,而Th17/Treg细胞的分化和功能受到细胞代谢重编程的影响。本文主要从与UC相关的肠相关淋巴组织以及固有层内多种免疫因素、Th17/Treg细胞代谢重编程以及中药免疫调节治疗UC现状3个方面进行综述,以期为UC相关研究提供参考。
Ulcerative colitis(UC)is a chronic nonspecific disease of the colon and rectum whose etiology is not well defined.UC is closely related to intestinal immunity.Intestinal-associated lymphoid tissue and lamina propria contain abundant immune cells,which play an important role in maintaining intestinal immune homeostasis.The imbalance of T helper cell(Th)17/T regulatory cell(Treg)was proved to be relative to intestinal immune homeostasis of UC,which was affected by metabolic reprogramming of cells.To provide a reference for UC research,this paper mainly reviewed the studies from three aspects:enteric-associated lymphoid tissue and various immune factors in lamina propria related to UC,metabolic reprogramming of Th17/Treg cells,and traditional Chinese medicine immune regulation treatment of UC.
作者
李洋
宋志前
鲁欣悦
王淳
彭诗涛
张婷
宁张弛
LI Yang;SONG Zhiqian;LU Xinyue;WANG Chun;PENG Shitao;ZHANG Ting;NING Zhangchi(Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010,China;Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)
出处
《中国中医基础医学杂志》
CAS
CSCD
2024年第1期168-175,共8页
JOURNAL OF BASIC CHINESE MEDICINE
基金
中国中医科学院科技创新工程项目(CI2021A04201)
中国中医科学院优秀青年科技人才(创新类)项目(ZZ14-YQ-035)
中央级公益性科研院所基本科研业务费专项(YZ202141)。
