摘要
目的 观察硝苯地平联合盐酸利托君治疗晚期先兆流产的临床效果。方法 回顾性选取2021年2月—2023年2月福建医科大学附属漳州市医院收治的晚期先兆流产患者50例,根据治疗方法不同分为联合组和对照组,各25例。联合组予硝苯地平联合盐酸利托君治疗,对照组予单纯盐酸利托君治疗。比较2组临床疗效,治疗前后患者炎性指标(中性粒细胞、超敏C反应蛋白、降钙素原)水平,相关临床指标(宫缩控制时间、症状缓解时间、妊娠延长时间)、围生儿不良结局及不良反应。结果 联合组治疗效果优良率为92.00%,高于对照组的68.00%(χ^(2)=4.500,P=0.034)。治疗14 d后,2组中性粒细胞、超敏C反应蛋白、降钙素原水平较治疗前降低,且联合组低于对照组(P<0.01)。联合组宫缩控制时间、症状缓解时间短于对照组,妊娠延长时间长于对照组(P<0.01);联合组围生儿不良结局总发生率为4.35%,低于对照组的29.41%(χ^(2)=4.816,P=0.028)。联合组与对照组不良反应总发生率比较差异无统计学意义(4.00%vs. 8.00%,P=1.000)。结论 硝苯地平联合盐酸利托君治疗晚期先兆流产可明显提高治疗效果,改善围生儿结局,尽可能延长妊娠时间,更有利于减轻炎性因子水平,且不会增加不良反应。
Objective To observe the clinical effect of nifedipine combined with ritodrine hydrochloride in the treatment of late threatened abortion.Methods A total of 50 patients with late threatened abortion admitted to Zhangzhou Affiliated Hospital of Fujian Medical University from February 2021 to February 2023 were retrospectively selected and divided into combined group and control group according to different treatment methods,with 25 cases in each group.The combined group was treated with nifedipine combined with ritodrine hydrochloride,and the control group was treated with ritodrine hydrochloride alone.The clinical efficacy,the levels of inflammatory indicators(NE,hs-CRP,PCT)before and after treatment,the related clinical indicators(symptom relief time,pregnancy extension time,uterine contraction control time),poor perinatal outcomes and adverse reactions were compared between the two groups.Results The total excellent and good rate of the combined group(92.00%)was higher than the control group(68.00%)(χ^(2)=4.500,P=0.034).After 14 days of treatment,the levels of NE,hs-CRP and PCT in the two groups were lower than those before treatment,and the levels in the combined group were lower than those in the control group(P<0.01).The uterine contraction control time and symptom relief time of the combined group were shorter than those of the control group,and the pregnancy extension time of the combined group was longer than that of the control group(P<0.01).The total incidence of poor perinatal outcomes in the combined group(4.35%)was lower than the control group(29.41%)(χ^(2)=4.816,P=0.028).There was no significant difference in the total incidence of adverse reactions between the combined group and the control group(4.00%vs.8.00%,P=1.000).Conclusion Nifedipine combined with ritodrine hydrochloride in the treatment of late threatened abortion can significantly improve the treatment effect,improve the perinatal outcome,prolong the gestational time as much as possible,and is more conducive to reduce the level of inflammatory factors,without increasing adverse reactions.
作者
蔡玉婷
蔡月云
张宇
CAI Yuting;CAI Yueyun;ZHANG Yu(Obstetrical Department,Zhangzhou Affiliated Hospital of Fujian Medical University,Fujian Province,Zhangzhou 363000,China)
出处
《临床合理用药杂志》
2023年第34期32-34,38,共4页
Chinese Journal of Clinical Rational Drug Use
关键词
先兆流产
晚期
硝苯地平
盐酸利托君
治疗效果
Threatened abortion,late
Nifedipine
Ritodrine hydrochloride
Treatment effect
