摘要
目的分析细胞角蛋白19片段(CYFRA21-1)、癌胚抗原(CEA)、鳞状上皮细胞癌抗原(SCC)、神经元特异性烯醇化酶(NSE)在肺癌患者中的表达意义。方法抽取2020年2月至2022年3月平煤神马医疗集团总医院收治的肺癌患者215例作为肺癌组,另抽取同期肺部良性病变者215例作为良性组及健康体检者215例作为健康对照组。三组均检测血清CYFRA21-1、CEA、SCC、NSE水平,比较三组上述四项指标表达水平及阳性检出率,比较肺癌组中不同分期(Ⅰ~Ⅱ期、Ⅲ~Ⅳ期)、不同预后(有淋巴结转移、无淋巴结转移)及治疗前后四项指标水平。结果肺癌组CYFRA21-1、CEA、SCC、NSE水平及其阳性检出率高于良性组和健康对照组(P<0.05)。肺癌组Ⅲ~Ⅳ期者CYFRA21-1、CEA、SCC、NSE水平高于Ⅰ~Ⅱ期者(P<0.05)。肺癌组中有淋巴结转移者CYFRA21-1、CEA、SCC、NSE水平高于无淋巴结转移者(P<0.05)。肺癌组治疗后CYFRA21-1、CEA、SCC、NSE水平低于治疗前(P<0.05)。结论CYFRA21-1、CEA、SCC、NSE在肺癌患者中表达水平及其阳性率较高,可用于评估肺癌临床分期、预后及治疗效果。
Objective To analyze the significance of expression of cytokeratin 19 fragment(CYFRA21-1),carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCC)and neuron-specific enolase(NSE)in patients with lung cancer.Methods A total of 215 lung cancer patients admitted to General Hospital of Pingmei Shenma Medical Group from February 2020 to March 2022 were selected as the lung cancer group;215 patients with benign lung lesions during the same period were selected as the benign group;and 215 healthy subjects were selected as the healthy control group.The three groups were tested for CYFRA21-1,CEA,SCC and NSE.The expression levels and positive detection rates of the four aforementioned indicators were compared among the three groups.The levels of the four indicators in patients at different stages of lung cancer,including stagesⅠtoⅡ,ⅢtoⅣ,in patients with different prognosis(with lymph node metastasis,without lymph node metastasis),and at different times(before and after treatment)were compared in the lung cancer group.Results The levels and positive detection rates of CYFRA21-1,CEA,SCC,and NSE in the lung cancer group were higher than those in the benign group and in the healthy control group(P<0.05).The levels of CYFRA21-1,CEA,SCC,and NSE in patients with stageⅢ-Ⅳlung cancer were higher than those in patients with stageⅠ-Ⅱ(P<0.05).In the lung cancer group,the levels of CYFRA21-1,CEA,SCC,and NSE in patients with lymph node metastasis were higher than those in patients without lymph node metastasis(P<0.05).The levels of CYFRA21-1,CEA,SCC,and NSE in the lung cancer group after treatment were lower than those before treatment(P<0.05).Conclusions The expression levels and positive rates of CYFRA21-1,CEA,SCC,and NSE are higher in patients with lung cancer,which can be used to evaluate the clinical staging,prognosis,and treatment effect of lung cancer.
作者
王耀飞
苌哲宗
杜帅格
孟盈君
Wang Yaofei;Chang Zhezong;Du Shuaige;Meng Yingjun(Department of Nuclear Medicine,General Hospital of Pingmei Shenma Medical Group,Pingdingshan 467000,China)
出处
《中国实用医刊》
2023年第21期12-15,共4页
Chinese Journal of Practical Medicine
