摘要
目的分析胃癌与慢性萎缩性胃炎(CAG)胃黏膜SLC26A9基因表达情况。方法回顾性分析200例过往CAG入院复查患者,以其中69例CAG患者为胃炎组,40例胃黏膜低级别上皮细胞瘤变患者为低级别瘤变组,34例胃黏膜高级别上皮细胞瘤变患者为高级别瘤变组,57例胃癌患者为胃癌组;胃癌组根据胃癌进展程度分为早期组(n=31)和进展期组(n=26)。200例患者均进行胃黏膜SLC26A9基因表达水平检测,比较胃炎组、低级别瘤变组、高级别瘤变组、胃癌组4组患者胃黏膜SLC26A9基因表达水平;比较早期组和进展期组患者胃黏膜SLC26A9基因表达水平。使用logistic相关性模型分析SLC26A9基因表达水平与胃癌发生、胃癌进展程度的相关性。使用受试者工作曲线(ROC)分析SLC26A9基因表达对胃癌的诊断价值;使用ROC曲线分析SLC26A9基因表达对胃癌进展程度的判断价值。结果胃炎组、低级别瘤变组、高级别瘤变组、胃癌组4组胃黏膜SLC26A9基因表达水平均存在明显差异,且胃炎组>低级别瘤变组>高级别瘤变组>胃癌组(P<0.05);早期组患者胃黏膜SLC26A9基因表达水平显著高于进展期组(P<0.05)。经logistic相关性分析,胃黏膜SLC26A9基因表达水平与胃癌发生、胃癌进展程度均呈负相关(P<0.05)。ROC曲线中,胃黏膜SLC26A9基因表达水平诊断胃癌发生的曲线下面积(AUC)为0.935,95%CI为0.892~0.965,敏感度为91.23%,特异度为87.41%,截断值为0.2787;胃黏膜SLC26A9基因表达水平诊断胃癌进展程度AUC为0.881,95%CI为0.768~0.952,敏感度为92.31%,特异度为80.65%,截断值为0.2368。结论胃黏膜SLC26A9基因表达水平与胃癌发生密切相关,可为临床诊断CAG患者疾病恶化为胃癌及其胃癌进展程度。
Objective To analyze the expression of SLC26A9 gene in gastric mucosa of gastric cancer or chronic atrophic gastritis(CAG).Methods 200 patients received re-examination due to past history of CAG were retrospectively analyzed.Among the the patients,69 cases with CAG were included in gastritis group,40 cases with low-grade gastric mucosal epithelial neoplasia were selected as low-grade neoplasia group,34 cases with high-grade gastric mucosal epithelial neoplasia were classified as high-grade neoplasia group,and 57 cases with gastric cancer were assigned to gastric cancer group.The patients in gastric cancer group were divided into early stage group(n=31)and advanced stage group(n=26)according to the degree of progression of gastric cancer.Gastric mucosa SLC26A9 gene expression level was detected among all 200 patients,and the SLC26A9 gene expression level in gastric mucosa was compared among gastritis group,low-grade neoplasia group,high-grade neoplasia group and gastric cancer group.The expression level of SLC26A9 gene in gastric mucosa was also compared between early stage group and advanced stage group.Logistic correlation analysis model was used to analyze the correlation between the expression level of SLC26A9 gene in gastric mucosa and the occurrence and progression degree of gastric cancer.Receiver operating characteristic curve(ROC)was adopted to analyze the diagnostic value of gastric mucosa SLC26A9 gene expression on gastric cancer.ROC curve was also applied to analyze the judgement value of SLC26A9 gene expression on progression degree of gastric cancer.Results There was a significant difference in the expression level of SLC26A9 gene in gastric mucosa among gastritis group,low-grade neoplasia group,high-grade neoplasia group and gastric cancer group,and the expression level was shown as gastritis group>low-grade neoplasia group>high-grade neoplasia group>gastric cancer group(P<0.05).The expression level of gastric mucosa SLC26A9 gene in early stage group was significantly higher than that in advanced stage group(P<0.05).According to logistic correlation analysis,the expression level of SLC26A9 gene in gastric mucosa was negatively correlated with the occurrence[LM]and progression degree of gastric cancer(P<0.05).The area under the ROC curve(AUC),95%CI,sensitivity,specificity and cut-off value of gastric mucosa SLC26A9 gene expression level were 0.935,0.892-0.965,91.23%,87.41%and 0.2787 in the diagnosis of occurrence of gastric cancer,and were 0.881,0.768-0.952,92.31%,80.65%and 0.2368 in the diagnosis of gastric cancer progression degree.Conclusion The expression level of SLC26A9 gene in gastric mucosa is closely related to the occurrence of gastric cancer,and it can be used for clinical diagnosis of disease deterioration to gastric cancer in patients with CAG and the degree of gastric cancer progression.
作者
买春阳
张健
闫振宇
MAI Chunyang;ZHANG Jian;YAN Zhenyu(Nanyang Central Hospital,Nanyang,473001)
出处
《实用癌症杂志》
2024年第1期26-29,共4页
The Practical Journal of Cancer
