摘要
目的探讨血清miR-374a、肿瘤特异性生长因子(TSGF)、鳞状细胞癌抗原(SCCAg)对早期宫颈癌淋巴结转移(LNM)的诊断价值。方法对收治的109例早期宫颈癌患者进行回顾性分析,根据术后病理有无LNM分为LNM组(28例)和无LNM组(81例),对可能影响宫颈癌LNM的相关因素进行单因素、Logistic回归分析,包括年龄、分化程度、FIGO分期、间质浸润深度、淋巴脉管间隙浸润(LVSI)、肿瘤直径及血清miR-374a、TSGF、SCCAg。ROC曲线评价血清miR-374a、TSGF及SCCAg诊断宫颈癌LNM的价值。结果单因素分析显示,间质浸润深度、LVSI、肿瘤直径、血清miR-374a、TSGF及SCCAg与宫颈癌LNM有关(P<0.05);年龄、分化程度、FIGO分期与宫颈癌LNM无关(P>0.05)。Logistic回归分析显示,间质浸润深度≥1/2、肿瘤直径≥2 cm、血清miR-374a、TSGF及SCCAg均是宫颈癌LNM的危险因素(P<0.05);LVSI与宫颈癌LNM无关(P>0.05)。ROC曲线显示,血清miR-374a、TSGF、SCCAg单独及三者联合诊断宫颈癌LNM的AUC分别为0.695、0.681、0.714、0.786,敏感度分别为53.57%、82.14%、78.57%、82.14%,特异度分别为90.12%、53.09%、65.43%、72.84%。结论血清miR-374a、TSGF及SCCAg是早期宫颈癌LNM的危险因素,有助于诊断早期宫颈癌LNM,且三者联合的诊断的效果更佳。
Objective To investigate the diagnostic value of serum miR-374a,tumor specific growth factors(TSGF)and squamous cell carcinoma antigen(SCCAg)for lymph node metastasis(LNM)of early cervical cancer.Methods 109 patients with early cervical cancer were retrospectively analyzed,according to the presence or absence of LNM in postoperative pathology,they were divided into LNM group(28 cases)and non-LNM group(81 cases),Univariate and logistic regression analysis were used to analyze the related factors that might affect the LNM of cervical cancer,including age,degree of differentiation,FIGO stage,depth of stromal invasion,lymphovascular space invasion(LVSI),tumor diameter and serum miR-374a,TSGF and SCCAg.ROC curve was used to evaluate the diagnostic value of serum miR-374a,TSGF and SCCAg for LNM of cervical cancer.Results Univariate analysis showed that depth of stromal invasion,LVSI,tumor diameter,serum miR-374a,TSGF and SCCAg were associated with LNM of cervical cancer(P<0.05);age,degree of differentiation and FIGO stage were not associated with LNM of cervical cancer(P>0.05).Logistic regression analysis showed that the depth of stromal invasion≥1/2,tumor diameter≥2 cm,serum miR-374a,TSGF and SCCAg were risk factors for LNM of cervical cancer(P<0.05);LVSI was not associated with LNM of cervical cancer(P>0.05).ROC curve showed that the AUC of serum miR-374a,TSGF,SCCAg alone and their combination in the diagnosis of LNM of cervical cancer were 0.695,0.681,0.714,0.786,respectively;the sensitivity were 53.57%,82.14%,78.57%,82.14%,respectively;and the specificity were 90.12%,53.09%,65.43%and 72.84%,respectively.Conclusion Serum miR-374a,TSGF and SCCAg are risk factors for LNM of early cervical cancer,which is helpful for the diagnosis of LNM of early cervical cancer,and the combination of the three has better diagnostic value.
作者
周颖
王淑丽
李红娟
田晓娜
王雅莉
ZHOU Ying;WANG Shuli;LI Hongjuan(Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou,450007)
出处
《实用癌症杂志》
2024年第1期42-45,50,共5页
The Practical Journal of Cancer
