摘要
目的探析血清趋化因子配体5(CXCL5)、可溶性细胞间黏附分子-1(sICAM-1)与非肌层浸润性膀胱癌(NMIBC)患者术后转归的关系。方法采用便利抽样法,选取118例接受手术治疗的NMIBC患者,术后对患者进行为期1年的随访,观察患者无瘤生存期。比较不同CXCL5、sICAM-1水平的患者临床病理特征和无瘤生存期情况;采用COX回归验证血清CXCL5、sICAM-1水平与患者术后无瘤生存期的关系;采用Kaplan-Meier生存分析检验不同CXCL5、sICAM-1水平患者的无瘤生存期。结果经双变量Pearson相关系数检验,NMIBC患者血清CXCL5、sICAM-1水平之间呈正相关(γ=0.328,P<0.001)。血清CXCL5、sICAM-1高表达组中NMP22≥10 U/ml、低分化患者占比高于低表达组,差异有统计学意义(P<0.05);但血清CXCL5、sICAM-1不同表达组的年龄、性别、TNM分期、病灶大小及病灶数量比较,差异无统计学意义(P>0.05)。118例NMIBC患者中,经为期1年的随访,有34例出现复发,复发率为28.81%;经单因素和多因素COX回归分析结果显示,血清CXCL5、sICAM-1水平与NMIBC患者无瘤生存情况有关(P<0.05);血清CXCL5、sICAM-1水平高表达组的总体无瘤生存时间均低于低表达组,差异有统计学意义(P<0.05)。结论血清CXCL5、sICAM-1水平与NMIBC患者术后转归具有一定的相关性。
Objective To explore the relationship between serum chemokine ligand 5(CXCL5),soluble intercellular adhesion molecule-1(sICAM-1)and postoperative outcome of non-muscular invasive bladder cancer(NMIBC).Methods The convenience sampling method was used to select 118 NMIBC patients who received surgical treatment.The patients were followed up for 1 year after operation to observe the tumor free survival period of the patients.The clinicopathological characteristics and tumor free survival of patients with different levels of CXCL5 and sICAM-1 were compared.COX regression was used to verify the relationship between serum CXCL5 and sICAM-1 levels and postoperative tumor free survival.Kaplan-Meier survival analysis was used to test the tumor free survival of patients with different levels of CXCL5 and sICAM-1.Results By bivariate Pearson correlation coefficient test,there was a positive correlation between serum CXCL5 and sICAM-1 levels in NMIBC patients(γ=0.328,P<0.001).The proportion of NMP22≥10 U/ml and low differentiation patients in the high expression group of serum CXCL5 and sICAM-1 was higher than that in the low expression group,the difference was statistically significant(P<0.05).However,there was no statistical significant difference in age,sex,TNM stage,lesion size and number of lesions between serum CXCL5 and sICAM-1 different expression groups(P>0.05).Among 118 patients with NMIBC,34 patients had relapse after one-year follow-up,with a recurrence rate of 28.81%.The results of univariate and multivariate COX regression analysis showed that serum CXCL5 and sICAM-1 levels were related to the tumor free survival of NMIBC patients(P<0.05).The overall tumor free survival time of high expression group of serum CXCL5 and sICAM-1 was lower than that of low expression group,the difference was statistically significant(P<0.05).Conclusion The levels of serum CXCL5 and sICAM-1 are correlated with the prognosis of NMIBC patients.
作者
朱其军
魏文焕
ZHU Qijun;WEI Wenhuan(Xinyang Central Hospital,Xinyang,464000)
出处
《实用癌症杂志》
2024年第1期64-69,共6页
The Practical Journal of Cancer
