摘要
目的梳理和总结天然药物及中药治疗急性肺损伤机制研究热点及发展趋势,为后续研究提供依据及可行性建议。方法检索CNKI数据库中天然药物及中药治疗急性肺损伤机制的相关文献,运用CiteSpace软件对关键词进行可视化展示。结果共纳入文献752篇,涉及关键词475个,形成11个具有代表性的聚类。该领域研究热点主要集中在天然药物及中药的抗炎症、抗氧化、调节细胞自噬和凋亡机制,在此过程中核因子κB是最常涉及的通路因子;研究的治疗药物包括天然药物活性成分、中药材和中成药。代谢组学、自噬、斑马鱼、分子对接、天然药物活性成分(柚皮素、贝母素甲、木犀草素、甘草酸)是近年研究的新兴主题,抗炎、抗氧化、细胞凋亡、中药材(丹参、川芎嗪、黄芪、大黄)则是跨度较长的经典主题。结论目前天然药物及中药治疗急性肺损伤研究涉及多种成分、多个靶点,代谢组学和分子对接技术将有助于对天然药物及中药作用机制进行系统研究。
Objective To sort out and summarize the research hotspots and development trends of the mechanism of natural medicines and traditional Chinese medicines in the treatment acute lung injury,and to provide basis and feasible suggestions for followup research.Methods The relevant literatures on the mechanism of natural medicines and traditional Chinese medicines in the treatment of acute lung injury in CNKI database were retrieved,and the keywords were visualized analyzed by CiteSpace.Results A total of 752 literatures were included,involving 475 keywords,forming 11 representative clusters.The hotspots in this field mainly focus on the anti-inflammatory,anti-oxidation,regulation of autophagy cell and apoptosis mechanisms of natural drugs.In this process,NF-κB was the most frequently involved target.The therapeutic drugs studied included the active ingredients of natural drugs,traditional Chinese medicine and traditional Chinese patent medicine.Metabolomics,autophagy,zebrafish,molecular docking,natural drug active ingredients(naringin,fritillarin A,luteolin,glycyrrhizic acid)were emerging topics of research in recent years,while anti-inflammatory,antioxidant,apoptosis,and traditional Chinese medicine(salvia miltiorrhiza,ligustrazine,astragalus,rhubarb)were classic topics with a long span.Conclusion At present,the research of natural medicines and traditional Chinese medicines in the treatment of acute lung injury involves many components and targets.Metabolomics and molecular docking technology will contribute to the systematic study of the mechanism of natural drugs and traditional Chinese medicines.
作者
彭静
李巧玲
梅艳
邢利鹏
高萍
刘林慧
Jing PENG;Qiao-Ling LI;Yan MEI;Li-Peng XING;Ping GAO;Lin-Hui LIU(Department of Pharmacy,Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital),Tongji Medical College,Huazhong University of Science&Technology,Wuhan 430016,China)
出处
《药物流行病学杂志》
CAS
2023年第11期1296-1304,共9页
Chinese Journal of Pharmacoepidemiology
基金
国家自然科学基金青年科学基金项目(82104300)
武汉市卫生计生委医学科研重点项目(WZ21A07)。
