摘要
目的 探讨临床特征联合血清糖类抗原(CA) 19-9、人附睾蛋白4 (HE4)对子宫内膜异位症相关卵巢癌症(EAOC)的诊断价值。方法 选择2020年1月至2022年12月在河南中医药大学第三附属医院接受手术且经术后病理确诊为EAOC的43例患者作为观察组,按照1∶2的比例抽取同期在我院手术且经术后证实为卵巢子宫内膜异位症(OEM)的86例患者作为对照组。比较两组患者的临床资料及血清CA125、CA19-9和HE4水平,采用多因素Logistic回归分析影响EAOC的独立风险因素,并采用受试者工作特征曲线(ROC)分析临床特征、CA19-9和HE4诊断EAOC的价值。结果 观察组患者的CA19-9和HE4水平分别为[20.99 (17.06,32.40)] U/mL和[64.47 (55.93,72.01)] U/mL,明显高于对照组的[4.98(2.18,10.86)] U/mL和[43.39(34.61,52.40)] U/mL,差异均有统计学意义(P<0.05);观察组患者的CA125水平为[59.85 (39.51,92.26)] pmol/L,明略高于对照组的[56.58 (39.80,80.68)] pmol/L,但差异无统计学意义(P>0.05)。经多因素Logistic回归分析结果显示,CA19-9、HE4、年龄、肿瘤最长径是影响EAOC的风险因素(P<0.05)。经ROC分析结果显示,年龄、肿瘤最长径、CA19-9、HE4联合检测的曲线下面积(AUC)为0.958,明显高于单独检测(年龄:0.857;肿瘤最长径:0.767;CA19-9:0.767;HE4:0.808)(P<0.05)。结论 CA19-9、HE4、年龄、肿瘤最长径可用于预测EAOC,联合检测可提高诊断效能。
Objective To investigate the diagnostic value of clinical features combined with serum carbohy-drate antigen(CA)19-9 and human epididymis protein 4(HE4)in endometriosis-associated ovarian cancer(EAOC).Methods Forty-three patients who underwent surgery and confirmed as EAOC by postoperative pathology in the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine from January 2020 to December 2022 were se-lected as the observation group.Eighty-six patients who underwent surgery in the hospital and were confirmed as ovari-an endometriosis(OEM)after surgery were selected as the control group according to the ratio of 1:2.The clinical data and serum levels of CA125,CA19-9,and HE4 were compared between two groups.Multivariate logistic regression anal-ysis was used to identify independent risk factors affecting EAOC,and the receiver operating characteristic curve(ROC)was used to analyze the value of clinical features,CA19-9 and HE4 in the diagnosis of EAOC.Results The levels of CA19-9 and HE4 in the observation group were[20.99(17.06,32.40)]U/mL and[64.47(55.93,72.01)]U/mL,respec-tively,which were significantly higher than[4.98(2.18,10.86)]U/mL and[43.39(34.61,52.40)]U/mL in the control group(P<0.05).The CA125 level in the observation group was[59.85(39.51,92.26)]pmol/L,which was slightly high-er than[56.58(39.80,80.68)]pmol/L in the control group,but the difference was not statistically significant(P>0.05).Multivariate logistic regression analysis showed that CA19-9,HE4,age and longest diameter of tumor were risk factors affecting EAOC(P<0.05).The results of ROC analysis showed that the area under the curve(AUC)of combined detec-tion of age,longest tumor diameter,CA19-9 and HE4 was 0.958,which was significantly higher than that of single de-tection(age:0.857;the longest diameter of tumor:0.767;CA19-9:0.767;HE4:0.808,P<0.05).Conclusion CA19-9,HE4,age,and longest diameter of tumor can be used to predict EAOC,and combined detection can improve diagnos-tic efficacy.
作者
陈丽
赵威
李珊珊
梁爽
丁瑞敏
CHEN Li;ZHAO Wei;LI Shan-shan;LIANG Shuang;DING Rui-min(Department of Clinical Laboratory,the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450003,Henan,CHINA;Department of Obstetrics and Gynecology,the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450003,Henan,CHINA)
出处
《海南医学》
CAS
2024年第1期76-79,共4页
Hainan Medical Journal
基金
河南省中医药科学研究专项课题(编号:20-21ZY2220)。
