摘要
目的观察应用盐酸氨溴索联合噻托溴铵治疗老年慢性阻塞性肺疾病(COPD)患者的临床疗效。方法选取165例在2019年8月至2020年12月于镇平县第二人民医院确诊的老年COPD患者,通过随机数表法平均分为三组,其中盐酸氨溴索组(A组)、噻托溴铵组(B组)以及两种药物联合治疗组(C组)各55例。A组使用盐酸氨溴索治疗,B组使用噻托溴铵治疗,C组使用盐酸氨溴索联合噻托溴铵治疗。在行1周治疗后,对比三组患者临床疗效,分别比较三组患者治疗前后肺功能、血清以及痰液中炎症因子水平变化,以及三组患者试验相关药物有无产生不良反应及其发生率差异。结果C组治疗有效率明显高于A、B两组,差异具有统计学意义(P<0.05)。治疗后三组肺呼气功能指标[第一秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、第一秒钟用力呼气容积与用力肺活量的比值(FEV_(1)/FVC)]水平均较治疗前升高,且C组高于A、B组,差异均有统计学意义(P<0.05)。治疗后三组痰液和血清炎症因子[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]水平较治疗前均下降,且C组低于A、B组,差异均有统计学意义(P<0.05),三组不良反应发生率差异无统计学意义(P>0.05)。结论盐酸氨溴索联合噻托溴铵治疗可以显著改善老年COPD患者的肺功能,减轻肺部炎症,疗效比单独用药更佳。
Objective To observe the clinical efficacy of ambroxol hydrochloride combined with tiotropium bromide in the treatment of elderly patients with chronic obstructive pulmonary disease(COPD).Methods A total of 165 elderly COPD patients diagnosed at the Second People's Hospital of Zhenping County from August 2019 to December 2020 were selected and randomly divided into three groups using a random number table method.Among them,there were 55 cases in the ambroxol hydrochloride group(group A),the tiotropium bromide group(group B),and the combination therapy group(group C).Group A was treated with ambroxol hydrochloride,group B was treated with tiotropium bromide,and group C was treated with ambroxol hydrochloride combined with tiotropium bromide.After one week of treatment,the clinical efficacy of three groups of patients was compared,and the changes in lung function,serum and sputum inflammatory factor levels were compared before and after treatment,as well as the differences in the incidence of adverse reactions and related drugs in the trial among the three groups of patients were compared.Results The effective rate of treatment in group C was significantly higher than that in groups A and B,and the difference was statistically significant(P<0.05).After treatment,the levels of pulmonary expiratory function indicators[first second forced expiratory volume(FEV_(1)),forced vital capacity(FVC),and The ratio of forced expiratory volume in the first second to forced Vital capacity(FEV_(1)/FVC)]in the three groups increased compared to before treatment,and group C was higher than group A and group B,with statistical significance(P<0.05).The levels of inflammatory factors in sputum and serum[interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)]in the three groups after treatment were all decreased compared with those before treatment,and the levels of inflammatory factors in IL-6,IL-8 and TNF-αin group C were lower than those in group A and B,with statistical significance(P<0.05).There was no statistically significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion The combination of ambroxol hydrochloride and tiotropium bromide can significantly improve lung function and alleviate pulmonary inflammation in elderly COPD patients,with better therapeutic effects than medication alone.
作者
李欣
仝铜
赵明玺
LI Xin;TONG Tong;ZHAO Mingxi(The Third Department of Internal Medicine(Respiratory),the Second People's Hospital of Zhenping County,Nanyang Henan 474250,China)
出处
《临床研究》
2024年第2期65-68,共4页
Clinical Research
关键词
慢性阻塞性肺疾病
盐酸氨溴索
噻托溴铵
chronic obstructive pulmonary disease
ambroxol hydrochloride
thiothoramine bromide
