摘要
目的观察阿加曲班联合尤瑞克林治疗对急性缺血性脑卒中(AIS)的颅内血流速度、炎性因子和神经元特异性烯醇化酶(NSE)、S100β蛋白的影响。方法选取228例AIS患者,按随机数字表法分为对照组(尤瑞克林治疗)、观察组(阿加曲班联合尤瑞克林治疗)各114例,比较两组临床疗效、美国国立卫生院神经功能缺损评分(NIHSS)评分、Rankin修订量表(mRS)评分、颅内血流速度、炎性因及NSE、S100β和不良反应。结果观察组总有效率高于对照组(P<0.05);治疗后观察组NIHSS、mRS评分及肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、NSE、S100β水平均低于对照组,颅内血流速度高于对照组(P<0.05);两组不良反应情况比较,差异无统计学意义(P>0.05)结论阿加曲班联合尤瑞克林可改善AIS神经功能、颅内血流速度,降低炎性因子和NSE、S100β,安全性较高。
Objective To observe the effects of agatroban combined with urinary kallidinogenase on intracranial blood flow velocity,inflammatory factors,neuron-specific enolase(NSE)and S100βin patients with acute ischemic stroke(AIS).Methods A total of 228 patients with AIS were selected.The patients were divided into a control group and an observation group by using random number table method,114 in each group.The control group was treated with urinary kallidinogenase and the observation group was treated with agattriban combined with urinary kallidinogenase.Clinical effects,National Institutes of Health Neurological Impairment Score(NIHSS)scores,Rankin Modified Scale(mRS)scores,intracranial blood flow velocity,serum inflammatory factors,NSE and S10oβas well as the incidence of adverse reactions were compared between the groups.Results The effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,NIHSS and mRS scores and serum levels of tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),interleukin-8(IL-8),NSE and S100βin the observation group were significantly lower than those in the control group,and the intracranial blood flow velocity in the observation group was higher than that in the control group(P<0.05).There is no statistically significant difference in the comparison of adverse reactions between the two groups.(P>0.05).Conclusions Agattriban combined with urinary kallidinogenase can improve the nerve function and intracranial blood flow velocity and reduce the levels of inflammatory factors,NSE and S100βin AIS patients.It has a high safety.
作者
王露丽
李立豪
丁娟
WANG Lu-li;LI Li-hao;DING Juan(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《实用医院临床杂志》
2024年第1期159-162,共4页
Practical Journal of Clinical Medicine
基金
河南省自然科学基金资助项目(编号:19231004250028)。
