摘要
脑部类淋巴系统(glymphatic system,GS)是脑脊液和间质溶质之间新定义的全脑血管周围转运网络,可促进脑代谢废物的清除。其复杂的网络由动脉周围脑脊液流入通路、星形胶质细胞介导的由水通道蛋白4(aquaporin 4,AQP4)支持的流体和溶质的对流运输以及静脉周流出通路组成。其功能障碍与各种神经系统疾病有关,并在脑出血(intracerebral hemorrhage,ICH)后脑水肿的病理、生理过程中起关键作用。对脑部GS和AQP4在生理和ICH后的相关研究进行分析,可进一步了解其在ICH后的风险评估、诊断、预后和治疗中的潜在用途,以及与中医中风的“玄府”理论的相关性。
The glymphatic system(GS)is a newly defined,brain-wide perivascular transport network between cerebrospinal fluid and interstitial solutes,promoting the clearance of metabolic waste from the brain.This complex network consists of the periarterial cerebrospinal fluid inflow pathway,astrocyte-mediated fluid and solutes convective transport supported by aquaporin 4(AQP4),and perivenous outflow pathway.Dysfunction of the GS is related to various neurological diseases and plays a crucial role in the pathological and physiological process of brain edema after intracerebral hemorrhage(ICH).Analyzing the relevant research on the brain GS and AQP 4 in physiological and ICH conditions can provide further insights into their potential applications in risk assessment,diagnosis,prognosis,and treatment after ICH,as well as their relevance to traditional Chinese medicine theories,such as the‘Xuanfu’theory in stroke.
作者
杨镇宇
张博(综述)
涂鄂文(审校)
YANG Zhenyu;ZHANG Bo;TU Ewen(Department of Neurology,College of Clinical Medicine,Hunan University of Chinese Medicine,Changsha 410036;Department of Neurology,Hunan Brain Hospital&Second People’s Hospital of Hunan Province,Changsha 410021,China)
出处
《临床与病理杂志》
2023年第10期1857-1864,共8页
Journal of Clinical and Pathological Research
基金
湖南省重点研发项目(2020SK2122)
湖南省教育厅湖南省研究生科研创新项目(CX20220824)。
关键词
脑部类淋巴系统
水通道蛋白4
脑出血
glymphatic system,brain
aquaporins 4
intracerebral hemorrhage
