摘要
蓝光是一种波长为400~500 nm的可见光,其对人体主要危害有损伤眼周及眼部结构、加速皮肤老化、抑制褪黑素分泌、造成皮肤色素沉着等。当前,关于蓝光导致皮肤色素沉着的研究较少,文章首次系统地整理了蓝光导致皮肤色素沉着的发生机制,其主要包含蓝光对视蛋白3、α-MSH-MC1R通路、黑皮素受体、细胞因子等产生影响最后导致黑素生成增加,引发皮肤色素沉着。为后续相关研究提供了思路与理论基础。
Blue light is a visible light in the wavelength range of 400-500 nm,which can cause damage to the periocular and ocular structures,accelerate skin aging,inhibit melatonin secretion,and cause skin pigmentation.Compared with UV light,blue light causes more intense and long-lasting skin pigmentation,but there are few studies on the mechanisms of skin pigmentation caused by blue light.In this review,the mechanisms of skin pigmentation caused by blue light have been systematically summarized.It is briefly described that,blue light affects melanocytes by mediating the effect of opsin 3 and finally increases the production of tyrosinase and dopachrome tautomerase(DCT),leading to increased melanin synthesis in the skin;blue light can also affect melanocortin receptor-1,which in turn affects the production of interleukin-1 and endothelin receptor-1,which in turn acts on melanocortin receptor-1 and finally affects theα-MSHMC1R pathway,leading to increased melanin.The final effect on theα-MSH-MC1R pathway leads to increased melanin synthesis,triggering skin pigmentation.This review could provide a better understanding of the mechanisms of skin pigmentation caused by blue light and provide a theoretical basis for subsequent studies.
作者
刘峻辰
孟宪瑶
凌霄
虞旦
郭苗苗
李丽
Junchen Liu;Xianyao Meng;Xiao Ling;Dan Yu;Miaomiao Guo;Li Li(Beijing Key Lab of Plant Resources Research and Development,Beijing Technology and Business University,Beijing 100048,China;Beijing Lan Divine Technology Co.,Ltd.,Beijing 100081,China)
出处
《日用化学工业（中英文）》
北大核心
2024年第1期90-94,共5页
China Surfactant Detergent & Cosmetics
