摘要
糖尿病视网膜病变(DR)是糖尿病常见的微血管病变之一,也是成人失明的主要原因。由此可见,寻找DR预防与治疗的特异性靶点至关重要。脂肪组织不仅是储存能量的组织,也是活跃的内分泌器官,可以释放多种细胞因子,称为脂肪因子。研究表明,脂肪因子在DR的发生发展中具有重要作用。脂肪因子不仅可以直接通过血液循环作用于血管内皮,还能通过影响交感神经系统活性、胰岛素敏感性等方式间接影响血管内皮功能,从而导致血管内皮细胞功能障碍,视网膜血管通透性增加、神经退行性变、新生血管形成,最终导致血-视网膜屏障破坏。近年来,一些新的脂肪因子在DR中的作用逐渐被重视,本文就新型脂肪因子在DR中的相关研究进行综述。
Diabetic retinopathy(DR)is one of the common microangiopathy in diabetes and the main cause of blindness in adults.It can be seen that it is very important to find the specific target of DR prevention and treatment.Adipose tissue is not only an energy storage tissue,but also an active endocrine organ,which can release a variety of cytokines,called adipokines.Studies have shown that adipokines play an important role in the occurrence and development of DR.Adipokines can not only directly act on vascular endothelium through blood circulation,but also indirectly affect vascular endothelial function by affecting the activity of sympathetic nervous system and insulin sensitivity,which leads to dysfunction of vascular endothelial cells,increased retinal vascular permeability,neurodegeneration and neovascularization,and finally leads to the destruction of blood-retinal barrier.In recent years,the role of some new adipokines in DR has been paid more and more attention.This paper reviews the related research of several new adipokines in DR.
作者
李猷娜
姚润莲
Li Youna;Yao Runlian(Inner Mongolia Medical University,Hohhot 010000,Inner Mongolia Autonomous Region,China;Department of Ophthalmology,the Fourth Affiliated Hospital of Inner Mongolia Medical University,Baotou 014000,Inner Mongolia Autonomous Region,China)
出处
《国际眼科杂志》
2024年第2期246-250,共5页
International Eye Science
