摘要
基于荧光内窥镜的实际应用确定陷波滤光片的技术指标,以光学薄膜理论为基础设计陷波滤光片结构,采用Essential Macleod软件辅助进行膜系设计,分析膜层敏感度,选择合适镀膜设备、工艺控制方法制备陷波滤光片。制备的滤光片通带透射率均值达到97%以上,截止背景达到OD6以上,透射波前畸变低于λ/4@632.8 nm,满足医疗健康微创精准手术的应用需求。
Fluorescence endoscope,which enables simultaneous visible light imaging and near-infrared fluorescence molecular imaging,is a result of advanced endoscopic theories and cutting-edge technologies.This instrument holds great potential to become an essential visual monitoring system in future targeted surgeries.The optical performance of the notch filter within the fluorescence endoscope plays a pivotal role in determining the clarity and precision of identifying fluorescence images of lesions,thereby influencing the endoscope's efficacy in supporting diagnostics and advancing precision medicine in clinical practice.Consequently,research into critical technologies related to notch filter for fluorescence endoscopy and the development of high-performance filter products demonstrate significant clinical application prospects and scientific significance.By aligning the operational principles of the fluorescence endoscope with the spectral profiles of corresponding fluorescent reagents,we can define the technical specifications for notch filter.Based on the theory of optical film,we have designed a notch filter utilizing K9 substrates,characterized by the deposition of notch coating and anti-reflective coating on both sides.The design of the notch coating was achieved by optimizing the matching of high and low refractive index coefficients,which is based on an in-depth comparison of the merits and drawbacks of Rugate filters,Rugate filters with step-change refractive index,methods for matching high and low refractive index coefficients,and other notch structures.Moreover,we employed Essential Macleod software in conjunction with various optimization synthesis methods to achieve high passband transmission,minimal ripple,excellent blocking property for the excitation light source,as well as a steep transition from the excitation spectrum to the emission spectrum.This approach ultimately enables efficient suppression of the excitation light and efficient capture of fluorescence signals,playing a crucial role in accurately identifying lesions.To ensure precise control,a plasma reaction magnetron sputtering coating device is selected after simulating and analyzing the standard deviation of film thickness.The coating process involves ultrasonic cleaning and drying of substrates to maintain cleanliness,followed by heating the vacuum chamber to 200℃and maintaining a constant temperature for 30 minutes to remove gas.This is followed by ion bombardment of substrates for 120 seconds to activate the surface.The deposition rates for Nb2O5 and SiO2 are both set at approximately 0.5 nm/s for coating applications.To ensure complete oxidation of the sputtered film,we employ an oxygen partial pressure sensor(λ-sensor)to monitor the deposition process and measure oxygen content.The system is equipped with an Optical Monitoring System(OMS)film thickness control system that uses a combination of Backward,Offset,and Forward algorithms to accurately calculate and correct the stop position of film thickness.This approach enables precise control over sensitive layer thickness in complex film systems,thereby reducing the impact of errors on the overall spectrum.By carefully selecting substrates with wavefront aberration control and implementing stringent coating process control methods,we ensure that the wavefront aberration remains belowλ/4@632.8 nm,effectively minimizing optical system aberrations.After two rounds of meticulous process optimization,the filter's average transmittance within the passband exceeds 97%,while maintaining an exceptional blocking capability of OD6 and a wavefront aberration belowλ/4@632.8 nm,meeting the demands for precision applications in medical and minimally invasive surgery.
作者
王忠连
任少鹏
高鹏
阴晓俊
赵帅锋
班超
董明
王瑞生
娄海宇
于志强
刘添昊
WANG Zhonglian;REN Shaopeng;GAO Peng;YIN Xiaojun;ZHAO Shuaifeng;BAN Chao;DONG Ming;WANG Ruisheng;LOU Haiyu;YU Zhiqiang;LIU Tianhao(Shenyang Academy of Instrumentation Science Co.,Ltd,Shenyang 110043,China)
出处
《光子学报》
EI
CAS
CSCD
2024年第1期230-238,共9页
Acta Photonica Sinica
基金
国家科技部创新方法工作专项(No.2020IM010400)。
关键词
荧光内窥镜
滤光片
陷波膜系
近红外荧光
吲哚菁绿
Fluorescent endoscopes
Filter
Notch film
Near-infrared fluorescence
Indocyanine green
