摘要
目的:分析并探究儿童神经母细胞瘤(NB)化疗后严重感染的影响因素及重组人粒细胞刺激因子(rhG-CSF)预防的应用效果,为临床提供依据。方法:回顾性分析2020年3月—2021年12月南阳市中心医院收治的100例NB患儿的一般资料,统计所有患儿在化疗治疗后严重感染的发生率,并统计临床上可能诱发感染的影响因素。将停止化疗24 h后立即接受rhG-CSF预防干预的患儿为观察组(n=57);将出现粒细胞缺乏现象后再接受rhG-CSF预防干预的患儿为对照组(n=43)。观察两组患者严重感染发生情况并分析其影响因素,比较rhG-CSF预防的应用效果。结果:100例患儿中严重感染发生率为27.00%(27/100)。NB患儿化疗后严重感染发生率单因素分析结果显示,不同患儿年龄、病情分期、远处转移、血清神经元特异性烯醇化酶(NSE)、手术切除、化疗药物、化疗持续时间等都会影响到患儿化疗后严重感染发生率,差异有统计学意义(χ2=5.372、6.222、6.322、5.983、4.785、10.079、7.193,P<0.05)。应用rhG-CSF干预治疗后,对照组严重感染发生率高于观察组,持续时间长于对照组,差异有统计学意义(χ^(2)=6.515;t=10.218,P<0.05)。结论:影响儿童NB化疗后严重感染的主要因素为患儿年龄、临床分期、血清NSE水平、选用的化疗药物、化疗的持续时间等,若能够在患儿化疗24 h后及时给予rhG-CSF干预治疗,则能显著降低患儿群体出现严重感染的概率,有利于更好地改善患儿的预后。
Objective:To analyze and investigate the factors influencing severe infection after chemotherapy for neuroblastoma(NB)in children and the effect of the application of recombinant human granulocyte-stimulating factor(rhG-CSF)for prevention to provide a clinical basis.Methods:The general data of 100 children with NB admitted to the hospital from March 2020 to December 2021 were retrospectively analyzed,and the incidence of serious infections after chemotherapy treatment in all children was counted,as well as the factors influencing the possible clinical triggers of infection.Children who received rhG-CSF prophylaxis 24 h after stopping chemotherapy were included as the observation group(n=57),and children who received rhG-CSF prophylaxis after the development of granulocyte deficiency were included as the control group(n=43).The occurrence of serious infections in the two groups was observed and the influencing factors were analyzed and the application effect of rhG-CSF prophylaxis was compared.Results:The incidence of serious infection among 100 children was 27.00%(27/100).univariate analysis of the incidence of serious infection after chemotherapy in children with NB showed that different children’s age,stage of disease,distant metastases,serum NSE,surgical resection,chemotherapy drugs,and duration of chemotherapy affected the incidence of serious infection after chemotherapy in children with statistically significant differences(χ^(2)=5.372,6.222,6.322,5.983,4.785,10.079,7.193,P<0.05).After the application of rhG-CSF intervention treatment,the incidence of serious infection in the control group was higher than that in the observation group and lasted longer than that in the control group,and the difference was statistically significant(χ^(2)=6.515;t=10.218,P<0.05).Conclusion:The main factors affecting severe infections after chemotherapy in children with NB are age,clinical stage,serum NSE level,selected chemotherapy drugs,and duration of chemotherapy,etc.If rhG-CSF can be given in time after 24 h of chemotherapy,it can significantly reduce the probability of severe infections in the child population and help improve the prognosis of children.
作者
杨兰
高林林
雷婉婷
Yang Lan;Gao Linlin;Lei Wanting(Nanyang Central Hospital,Nanyang,Henan,473000,China)
出处
《黑龙江医学》
2024年第1期24-26,共3页
Heilongjiang Medical Journal
关键词
儿童神经母细胞瘤
化疗治疗
严重感染
影响因素
重组人粒细胞
刺激因子
预防应用
Childhood neuroblastoma
Chemotherapy treatment
Severe infection
Influencing factors
Recombinant human granulocytes
Stimulating factor
Prophylactic application
