摘要
目的探讨血清鸢尾素(Irisin)、甲状腺过氧化物酶抗体(TPOAb)联合对孕妇妊娠期甲状腺功能减退(简称甲减)的诊断价值。方法选取2020年10月至2022年10月于该院诊治的107例妊娠期甲减孕妇作为研究组,另选取107例同期在本院体检,且一般资料与妊娠期甲减孕妇相匹配的健康孕妇及107例非妊娠期健康女性分别作为对照组和健康组。采用Pearson法分析妊娠期甲减孕妇血清Irisin和TPOAb水平的相关性;采用Logistic回归分析影响妊娠期甲减发生的相关因素;采用受试者工作特征(ROC)曲线分析血清Irisin和TPOAb水平对妊娠期甲减的诊断价值。结果研究组血清Irisin和TPOAb水平均明显高于健康组及对照组(P<0.05);妊娠期甲减孕妇血清Irisin和TPOAb水平呈正相关(r=0.641,P<0.05);研究组孕前体质量指数(BMI)<20 kg/m 2、碘摄入量不足的孕妇所占比例高于对照组(P<0.05);孕前BMI<20 kg/m 2、碘摄入量不足、Irisin及TPOAb水平升高均为孕妇发生妊娠期甲减的危险因素(P<0.05);血清Irisin和TPOAb诊断妊娠期甲减的曲线下面积(AUC)分别为0.765、0.835,而二者联合诊断的AUC为0.926,二者联合优于血清Irisin、TPOAb单独诊断(Z二者联合-Irisin=6.105、Z二者联合-TPOAb=4.951,P均<0.001)。结论血清Irisin和TPOAb水平的升高与妊娠期甲减的发生密切相关,二者联合检测对妊娠期甲减具有较高的诊断价值。
Objective To explore the value of serum Irisin and thyroid peroxidase antibody(TPOAb)in the diagnosis of hypothyroidism during pregnancy.Methods A total of 107 pregnant women with hypothyroidism during pregnancy who were diagnosed and treated in the hospital from October 2020 to October 2022 were regarded as the study group,another 107 healthy pregnant women who were examined in the hospital at the same time and whose general data matched with cases of hypothyroidism during pregnancy and 107 non pregnant healthy women were taken as the control group and health group.Pearson method was applied to analyze the correlation between the levels of serum Irisin and TPOAb in pregnant women with hypothyroidism during pregnancy.Logistic regression was applied to analyze the related factors affecting the occurrence of hypothyroidism during pregnancy.The diagnostic value of serum Irisin and TPOAb levels for hypothyroidism during pregnancy was analyzed by the receiver operating characteristic(ROC)curve.Results The levels of serum Irisin and TPOAb in the study group were significantly higher than those in the health group and control group(P<0.05).The levels of serum Irisin and TPOAb in pregnant women with hypothyroidism during pregnancy were positively correlated(r=0.641,P<0.05).The proportions of pregnant women with BMI<20 kg/m 2 and iodine deficiency before pregnancy in the study group were obviously higher than those in the control group(P<0.05).BMI<20 kg/m 2 before pregnancy,iodine deficiency,increased levels of Irisin and TPOAb were all risk factors for hypothyroidism during pregnancy(P<0.05).The area under the curve(AUC)of serum Irisin and TPOAb in the diagnosis of hypothyroidism during pregnancy was 0.765 and 0.835,respectively,while the AUC of the combined diagnosis of the two was 0.926,the combined diagnosis of the two was better than that of serum Irisin and TPOAb alone(Z combination-Irisin=6.105,Z combination-TPOAb=4.951,P<0.001).Conclusion The increased levels of serum Irisin and TPOAb are closely related to the occurrence of hypothyroidism during pregnancy,and the combination of them has high diagnostic value for hypothyroidism during pregnancy.
作者
陈军
向婧
姚茂篪
CHEN Jun;XIANG Jing;YAO Maochi(Department of Endocrinology,Minda Hospital of Hubei Minzu University,Enshi,Hubei 445000,China;Department of General Medicine,Minda Hospital of Hubei Minzu University,Enshi,Hubei 445000,China)
出处
《国际检验医学杂志》
CAS
2024年第2期175-178,183,共5页
International Journal of Laboratory Medicine
基金
恩施州医疗卫生类指导性项目(JCY2019000034)。
