摘要
目的 探究艾司西酞普兰应用于急性脑梗死后焦虑抑郁患者的效果及对其神经功能、心理状态的影响。方法 选取我院2020年3月~2022年10月95例脑梗死后焦虑抑郁患者,根据抽签法分组。对照组47例给予结构式心理干预,观察组48例增加艾司西酞普兰治疗,对比两组患者情绪(汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分);神经功能(神经元特异性稀醇化酶(NSE)、基质细胞衍生因子-1(SDF-1)、视锥蛋白样蛋白-1(VILIP-1)水平);以及自我管理能力(慢性病自我管理研究测量表各项评分)。结果 治疗后两组慢性病自我管理研究测量表各项评分组间无统计学意义(P>0.05)。治疗后观察组HAMA、HAMD评分、NSE、VILIP-1水平低于对照组,SDF-1水平高于对照组,有统计学意义(P<0.05)。结论 相较于结构式心理干预,艾司西酞普兰联合结构式心理干预对改善脑梗死后焦虑抑郁患者自我管理能力效果相当,但其改善神经功能和心理状态效果更佳。
Objective To investigate the effect of escitalopram on anxiety and depression patients after acute cerebral infarction and its impact on neurological function and psychological status.Methods 95 patients with anxiety and depression after cerebral infarction in our hospital from March 2020 to October 2022 were selected and grouped according to the lottery method.47 patients in the control group received structured psychological intervention,while 48patients in the observation group received additional treatment with escitalopram.The psychological states[(Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD)],Neurological function[neuron specific enolase(NSE),stromal cell derived factor-1(SDF-1),and cone like protein-1(VILIP-1)],and self management ability(various scores on the chronic disease self-management research measurement table)of the two groups of patients were compared.Results After treatment,there was no statistically significant difference between the two groups in the scores of the chronic disease self-management study measurement table(P>0.05).After treatment,the HAMA,HAMD scores,NSE,and VILIP-1 levels in the observation group were lower than those in the control group,while the SDF-1 levels were higher than those in the control group,with statistical significance(P<0.05).Conclusion Compared to structured psychological intervention,the combination of escitalopram and structured psychological intervention has a similar effect on improving self-management ability in patients with anxiety and depression after cerebral infarction,but its effect on improving neurological function and psychological state is better.
作者
杜培培
王娇
张瑶
刘越
姜珊
刁德敦
王丙聚
姬利
DU Peipei;WANG Jiao;ZHANG Yao(Department of Neurology,Xianyang Hospital,Yan'an University,Xianyang 712000,China)
出处
《国际精神病学杂志》
2023年第6期1505-1508,共4页
Journal Of International Psychiatry
基金
陕西省重点研发计划项(编号:2020SF-150)
血尿酸水平与脑小血管病患者认知障碍的相关性研究(编号:2021ZDYF-SF-0059)。
关键词
艾司西酞普兰
结构式心理干预
脑梗死
焦虑抑郁
Escitalopram
Structural psychological intervention
Cerebral infarction
Anxiety and depression
