摘要
脑类淋巴系统是驱动脑内代谢产物清除的重要途径,其功能改变可以通过沿血管周围间隙扩散张量成像分析(DTI-ALPS)进行无创性评估。目前,DTI-ALPS方法已被广泛用于评估脑类淋巴系统相关疾病的改变,包括阿尔茨海默病(AD)、帕金森病(PD)、癫痫、脑小血管病(CSVD)、脑卒中及其他系统疾病等。现介绍DTI-ALPS方法的基本原理及技术进展,并就其在脑类淋巴系统中的应用予以综述。
The brain glymphatic system is an important pathway for the clearance of metabolic waste in the brain,and its functional changes can be non-invasively evaluated through diffusion tensor image analysis along the perivascular space(DTI-ALPS).Currently,the DTI-ALPS method has been widely used to assess changes in brain glymphatic system diseases,spanning conditions such as Alzheimer’s disease(AD),Parkinson’s disease(PD),epilepsy,cerebral small vessel disease(CSVD),stroke,and other systemic diseases.This article introduces the basic principles and technological progress of the DTI-ALPS method and reviews its application in the brain glymphatic system.
作者
廉馨莹
高晓
刘学焕
刘筠(审校)
LIAN Xinying;GAO Xiao;LIU Xuehuan;LIU Jun(Clinical College of The Fourth Center of Tianjin Medical University,Tianjin 300143,China;Department of Radiology,Tianjin Union Medical Centre;The Fourth Affiliated Central Hospital of Nankai University)
出处
《国际医学放射学杂志》
2024年第1期37-42,共6页
International Journal of Medical Radiology
基金
国家自然科学基金面上项目(12174203)
天津市科学技术局面上项目(21JCYBJC00120)
天津市教委科研计划项目(2022KJ268)
天津市卫生健康委员会天津市中医药管理局中医中西医结合重点项目(2021029)。
关键词
类淋巴系统
磁共振成像
沿血管周围间隙的扩散张量成像分析
中枢神经系统
Glymphatic system
Magnetic resonance imaging
Diffusion tensor image analysis along the perivascular space
Central nervous system
