摘要
目的:探讨超声颈项透明层厚度(NT)、子宫颈长度(LC)联合游离人绒毛膜促性腺激素(B-HCG)、妊娠相关血浆蛋白(PAPPA)、D二聚体(D-D)评估高危妊娠产妇妊娠结局的价值。方法:回顾性选取2019年1月至2022年1月在我院就诊的高危妊娠产妇80例作为研究对象,根据是否发生不良妊娠结局分为有不良妊娠结局组和无不良妊娠结局组,比较两组NT、LC、动脉S/D、PI、RI以及血清B-HCG、PAPPA、D-D的差异,以及指标间的相关性和对不良妊娠结局的预测价值。结果:有不良妊娠结局产妇的B-HCG、PAPPA、D-D和NT分别为(2.28±0.62)mom、(0.72±0.16)mom、(351.12±82.80)mg/L和(3.78±0.81)mm,明显高于无不良妊娠结局产妇(1.75±0.41)mom、(0.57±0.15)mom、(295.33±85.52)mg/L和(3.31±0.64)mm(P<0.01),而LC为(24.49±4.53)mm,明显低于无不良妊娠结局产妇(31.01±5.12)mm(P<0.01)。B-HCG、PAPPA、D-D水平与NT呈正相关(P<0.05),而与LC呈负相关(P<0.05)。NT、LC联合B-HCG、PAPPA、D-D预测高危妊娠产妇不良妊娠结局的ROC曲线下面积为0.911(95CI:0.848~0.974),明显高于各指标单独预测,其灵敏性和特异性分别为79.20%和96.30%,P<0.01。结论:NT、LC及B-HCG、PAPPA、D-D与高危妊娠产妇不良妊娠结局有相关性,在预测高危妊娠产妇不良妊娠结局中有较好的价值。
Objective:To explore the value of combined measurement of nuchal translucency(NT),cervical length(LC),free beta-human chorionic gonadotropin(B-HCG),pregnancy-associated plasma protein-A(PAPPA),and D-dimer(D-D)in assessing pregnancy outcomes in high-risk pregnant women.Methods:A retrospective study included 80 high-risk pregnant women who visited our hospital from January 2019 to January 2022.Participants were categorized into groups with adverse pregnancy outcomes and those without.The differences in NT,LC,arterial S/D ratio,PI,RI,serum B-HCG,PAPPA,and D-D levels were compared between the two groups.The correlation between these indicators and their predictive value for adverse pregnancy outcomes were analyzed.Results:Pregnant women with adverse pregnancy outcomes had significantly higher levels of B-HCG,PAPPA,D-D,and NT(2.28±0.62 mom,0.72±0.16 mom,351.12±82.80 mg/L,and 3.78±0.81 mm,respectively)compared to those without adverse outcomes(1.75±0.41 mom,0.57±0.15 mom,295.33±85.52 mg/L,and 3.31±0.64 mm,respectively)(P<0.01).LC was significantly lower in women with adverse outcomes(24.49±4.53 mm)compared to those without adverse outcomes(31.01±5.12 mm)(P<0.01).B-HCG,PAPPA,and D-D levels were positively correlated with NT(P<0.05),while negatively correlated with LC(P<0.05).The combined use of NT,LC,B-HCG,PAPPA,and D-D in predicting adverse pregnancy outcomes in high-risk pregnant women had an AUC of 0.911(95%CI:0.848-0.974),significantly higher than individual indicators.The sensitivity and specificity were 79.20%and 96.30%,respectively(P<0.01).Conclusion:NT,LC,B-HCG,PAPPA,and D-D are correlated with adverse pregnancy outcomes in high-risk pregnant women,and their combined use has good predictive value for adverse pregnancy outcomes in high-risk pregnancies.
作者
陈高进
张童茜
冯菲
CHEN Gaojin;ZHANG Tongxi;FENG Fei(The First Hospital of Lanzhou University,Gansu Lanzhou 730000,China)
出处
《河北医学》
2024年第1期111-115,共5页
Hebei Medicine
基金
甘肃省科技计划项目,(编号:21JR7RA661)。
关键词
高危妊娠
妊娠结局
颈项透明层厚度
子宫颈长度
游离人绒毛膜促性腺激素
妊娠相关血浆蛋白
D二聚体
High risk pregnancy
Pregnancy outcome
Thickness of neck transparent layer
Length of cervix
Free human chorionic gonadotropin
Pregnancy related plasma protein
D dimer
