摘要
目的:探讨血液粘度、网织血小板及血小板参数检测在老年免疫性血小板减少症(immune thrombocytopenia,ITP)患者中的诊断价值。方法:收集本院2020年至2022年82例老年(60岁以上)ITP患者为观察组,50例老年非免疫性血小板减少症(non-immune thrombocytopenia,NITP)(包括肝硬化病人25例、血液病15例、其他肿瘤患者10例)患者为对照1组,同期收集50例老年健康体检者为对照2组。采集血液,利用血流变分析仪检测血液粘度;全自动血细胞分析仪检测血小板(PLT)、网织血小板(reticulated platelet,RP)、血小板参数[血小板分布宽度(PDW)、血小板平均体积(MPV)、大血小板比率(P-LCR)]。对比分析各组治疗前后血液粘度、RP、PDW、MPV、P-LCR情况。结果:治疗前各组结果比较分析显示观察组PDW、MPV、网织血小板比率均高于对照1组和对照2组,血液粘度低于对照1组和对照2组,差异有统计学意义(P<0.05);对照1组和对照2组差异无统计学意义(P>0.05),同时随着观察组血小板减低,PDW、MPV升高越明显,血液粘度越低,观察组及对照组在疾病的比较中,差异有统计学意义(P<0.05);治疗前后结果比较分析,观察组重度和轻中度患者治疗后的血液粘度、PLT均高于治疗前(P<0.05),RP、P-LCR、PDW、MPV均明显减低并低于治疗前,差异有统计学意义(P<0.05)。结论:测定血液粘度、网织血小板、血小板参数对于评估老年ITP病因诊断及病情评估价值效果显著,同时对预后疗效评估有积极作用,可为临床提供充分的诊断支持。
Objective:To explore the diagnostic value of blood viscosity,reticulated platelets,and platelet parameters in elderly patients with immune thrombocytopenia(ITP).Methods:A total of 82 elderly(age 60 and above)ITP patients from our hospital between 2020 and 2022 were included as the observation group.The control group included 50 elderly patients with non-immune thrombocytopenia(NITP)(25 cases with cirrhosis,15 cases with hematological diseases,and 10 cases with other tumors).Another 50 elderly health examination participants were included as the second control group.Blood samples were collected for blood rheology analysis,including blood viscosity using a hemorheology analyzer,and platelet parameters[platelet distribution width(PDW),mean platelet volume(MPV),platelet-large cell ratio(P-LCR)]using an automated hematology analyzer.Comparative analysis of blood viscosity,reticulated platelets,PDW,MPV,and P-LCR before and after treatment was performed.Results:Before treatment,the observation group showed higher PDW,MPV,and reticulated platelet ratio compared to both control groups,while blood viscosity was lower,with statistical significance(P<0.05).There was no significant difference between Control Group 1 and Control Group 2(P>0.05).As the platelet count decreased in the observation group,PDW and MPV increased,and blood viscosity decreased,showing statistically significant differences between the obser-vation group and the control groups(P<0.05).Comparative analysis before and after treatment showed that in the observation group,the blood viscosity and platelet count of severe and mild-to-moderate patients in-creased after treatment(P<0.05),while reticulated platelets,P-LCR,PDW,and MPV significantly de-creased and were lower than before treatment,with statistical significance(P<0.05).Conclusion:Determi-ning blood viscosity,reticulated platelets,and platelet parameters significantly contributes to the etiological di-agnosis and disease assessment of elderly ITP patients.Additionally,it plays a positive role in prognosis eval-uation,providing ample diagnostic support for clinical practice.
作者
杨秋婷
朱艳君
范永丽
YANG Qiuting;ZHU Yanjun;FAN Yongli(Chengde Traditional Chinese Medicine,Hebei Chengde 067000,China)
出处
《河北医学》
2024年第1期130-134,共5页
Hebei Medicine
基金
河北省承德市2022年承德市科学技术研究与发展计划项目,(编号:202204A020号)。
