摘要
抑郁症作为常见的情感类精神障碍疾病,已成为世界范围内第二大健康负担。抑郁症表现出的一个重要特点是女性患抑郁症的可能性是男性的两倍以上,这可能与女性神经内分泌激素水平的变化有关,比如围产期抑郁、围绝经期抑郁(perimenopausal depression,PMD)。围绝经期是女性生殖的脆弱窗口,受各方面因素的影响,尤其是体内激素水平的波动使下丘脑-垂体-肾上腺(hypothalamic-pituitary-adrenal,HPA)轴和下丘脑-垂体-性腺(hypothalamus-pituitary-gonadal,HPG)轴功能发生紊乱,导致机体出现情绪低落和焦虑不安等抑郁症状。本文综述近年来HPA轴和HPG轴相互作用导致围绝经期抑郁症的研究进展,以期为围绝经期抑郁症以及抑郁症的诊断与治疗提供新的思路及参考。
As a common affective disorder,depression has become the second largest health burden worldwide.An important feature of depression is that women are twice more likely to develop depression,which may be related to changes in neuroendocrine hormones,such as perinatal depression,perimenopausal depression(PMD).Perimenopause is a fragile window of female reproduction,which is more affected by various factors,espeically the fluctuation of hormone levels in the hypothalamic-pituitary-adrenal hypothalamic-pituitary-adrenal(HPA)axis and hypothalamus-pituitary-gonadal(HPG)axis,leading to the body's depression,anxiety and other depressive symptoms.This paper reviews the research progress of HPA axis and HPG axis and perimenopausal depression in recent years,in order to provide new ideas and reference value for the diagnosis and treatment of perimenopausal depression and depression.
作者
刘晓钰
钱欣
韩玉苹
顾思梦
LIU Xiaoyu;QIAN Xin;HAN Yuping;GU Simeng(School of Medicine,Jiangsu University,Zhenjiang 212000,China)
出处
《中国健康心理学杂志》
2024年第2期161-167,共7页
China Journal of Health Psychology
基金
国家自然科学基金青年项目(编号:82101602)。
