摘要
目的:观察斑蝥酸钠维生素B_(6)注射液联合顺铂治疗恶性胸腔积液的效果。方法:选取2022年1月—2023年4月江西省胸科医院收治的60例恶性胸腔积液患者,用随机数字表法分为对照组和治疗组,各30例。对照组采用单纯顺铂胸腔灌注,治疗组采用顺铂联合斑蝥酸钠维生素B_(6)注射液胸腔灌注。比较两组近期疗效、不良反应、肿瘤标志物及血清T细胞亚群。结果:治疗组完全缓解率和总有效率均高于对照组,差异均有统计学意义(P<0.05)。治疗组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。治疗后1个月,治疗组CEA、CA125及CA199均低于对照组,差异均有统计学意义(P<0.05)。治疗后1个月,治疗组CD4^(+)T细胞、CD8^(+)T细胞及CD4^(+)/CD8^(+)均高于对照组,差异均有统计学意义(P<0.05)。结论:对恶性胸腔积液患者,斑蝥酸钠维生素B_(6)与顺铂联合胸腔灌注,近期疗效较佳,加强抗癌抑癌效应,能有效减少不良反应,机体免疫力可受到保护并有一定程度的提升。
Objective:To observe the effiect of Disdium Cantharidinate and Vitamin B_(6)Injection combined with Cisplatin in the treatment of malignant pleural effusion.Method:A total of 60 patients with malignant pleural effusion admitted to Jiangxi Provincial Chest Hospital from January 2022 to April 2023 were selected and divided into the control group and the treatment group by random number table method,with 30 cases in each group.The control group was treated with Cisplatin intrapleural perfusion,and the treatment group was treated with Cisplatin combined with Disdium Cantharidinate and Vitamin B_(6)Injection intrapleural perfusion.The short-term curative effect,adverse reaction,tumor markers and serum T cell subgroup in the two groups were compared.Result:The complete response rate and total effective rate in the treatment group were higher than those in the control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the treatment group was lower than that in the control group,the difference was statistically significant(P<0.05).1 month after treatment,CEA,CA125 and CA199 in the treatment group were lower than those in the control group,the differences were statistically significant(P<0.05).1 month after treatment,CD4^(+)T cells,CD8^(+)T cells and CD4^(+)/CD8^(+)in the treatment group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:For patients with malignant pleural effusion,intrapleural infusion of Disdium Cantharidinate and Vitamin B_(6)combined with Cisplatin has a good short-term effect.It can strengthen the anticancer and tumor suppressive effect,effectively reduce adverse reactions,and protect the body's immunity to a certain degree.
作者
熊鑫
史芳
杨银妹
李瑶
晏亮
XIONG Xin;SHI Fang;YANG Yinmei;LI Yao;YAN Liang(Second Department of Oncology,Jiangxi Provincial Chest Hospital,Nanchang 330006,China;不详)
出处
《中国医学创新》
CAS
2024年第1期35-39,共5页
Medical Innovation of China
基金
江西省卫生健康委科技计划项目(202211275)。
关键词
恶性胸腔积液
斑蝥酸钠维生素B_(6)
顺铂
Malignant pleural effusion
Disdium Cantharidinate and Vitamin B_(6)
Cisplatin
