摘要
目的探讨达格列净与二甲双胍、甘精胰岛素联合治疗老年2型糖尿病的效果。方法将80例老年2型糖尿病患者随机分为两组。两组均采用二甲双胍治疗,在此基础上对照组采用甘精胰岛素治疗,观察组采用达格列净联合甘精胰岛素治疗。比较两组的血糖水平、胰岛素相关指标、不良反应发生率。结果治疗后,观察组血糖水平低于对照组,胰岛素相关指标优于对照组(P<0.05)。观察组不良反应发生率为15.00%,与对照组的12.50%比较无统计学差异(P>0.05)。结论达格列净与二甲双胍、甘精胰岛素联合治疗老年2型糖尿病的效果较好,可强化患者血糖调控,改善胰岛功能,安全可靠,临床价值显著。
Objective To analyze the effect of dapagliflozin combined with metformin and insulin glargine in the treatment of elderly patients with type 2 diabetes mellitus.Methods 80 elderly patients with type 2 diabetes mellitus were randomly divided into two groups.Both groups were treated with metformin.On this basis,the control group was treated with insulin glargine,an the observation group was treated with dapagliflozin and insulin glargine.The blood glucose levels,insulin-related indicators and incidence of adverse reactions were compared between the two groups.Results After treatment,the blood glucose levels of the observation group were lower than those of the control group,and the insulin-related indicators were better than those of the control group(P<0.05).The incidence of adverse reactions in observation group was 15.00%,which had no statistical difference with 12.50%in the control group(P>0.05).Conclusions Dapagliflozin combined with metformin and insulin glargine in the treatment of elderly patients with type 2 diabetes mellitus has better effect,which can effectively enhance the regulation of blood glucose and improve the islet function,and is safe and reliable,with significant clinical value.
作者
张文博
郭宇
袁园
胡建龙
ZHANG Wenbo;GUO Yu;YUAN Yuan;HU Jianlong(Department of Endocrinology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)
出处
《临床医学工程》
2024年第1期43-44,共2页
Clinical Medicine & Engineering
基金
河南省医学科技攻关计划联合共建项目(LHGJ20190550)。
